Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature

Data source

Reference
Reference Type:
publication
Title:
Glycidyloxy Compounds Used in Epoxy Resin Systems: A Toxicology Review
Author:
Gardiner Thomas H & al
Year:
1992
Bibliographic source:
REGULATORY TOXICOLOGY AND PHARMACOLOGY 15, S1 -S77 ( 1992)

Materials and methods

Test material

Constituent 1
Chemical structure
Reference substance name:
Oxirane, mono[(C8-10-alkyloxy)methyl] derivs.
EC Number:
271-845-2
EC Name:
Oxirane, mono[(C8-10-alkyloxy)methyl] derivs.
Cas Number:
68609-96-1
Molecular formula:
C11H22O2, C12H24O2, C13H26O2
IUPAC Name:
2-[(decyloxy)methyl]oxirane; 2-[(octyloxy)methyl]oxirane
Test material form:
liquid

Test animals / tissue source

Species:
rabbit

Results and discussion

In vivo

Results
Irritation parameter:
other:
Remarks on result:
other: slight hyperemia of eyelid and conjunctiva

Applicant's summary and conclusion

Interpretation of results:
Category 2 (irritating to eyes) based on GHS criteria
Conclusions:
The eye irritation potential of alkyl GEs has been tested in rabbits. C8-C10 elicited mild eye irritation and produced only slight to moderate conjunctivitis that cleared in 1 day.