Registration Dossier
Registration Dossier
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EC number: 242-560-0 | CAS number: 18765-38-3
Endpoint summary
Administrative data
Description of key information
In a Buehler test conducted according to OECD 406 and in compliance with
GLP (Hüls, 1992c) tetrakis(2-butoxyethyl) orthosilicate was found to be
not sensitising.
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
In a Buehler test conducted according OECD TG 406 and in compliance with GLP (Hüls, 1992c), Dunkin Hartley guinea pigs were treated (10/10 control/test group) for three six-hour induction phases (using 100% test substance in phases 1 and 2, and 50% in corn oil in phase 3) during which there was mild irritation in some animals. None of the guinea-pigs showed any skin reactions in the challenge phase and hence tetrakis(2-butoxyethyl) orthosilicate was concluded not to be a skin sensitiser.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Based on the available data tetrakis(2-butoxyethyl) orthosilicate does not require classification for sensitisation according to Regulation (EC) No 1272/2008.
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