Registration Dossier
Registration Dossier
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EC number: 235-595-8 | CAS number: 12336-95-7
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Pas applicable
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Toxicological review of trivalent chromium. In Support of Summary Information on the Integrated Risk Information System (IRIS
- Author:
- Grevatt PC
- Year:
- 1 998
- Bibliographic source:
- U.S. Environmental Protection Agency Washington, DC, USA, 51 p.
Materials and methods
- Objective of study:
- absorption
- distribution
- excretion
- metabolism
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 417 (Toxicokinetics)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Chromium trichloride
- EC Number:
- 233-038-3
- EC Name:
- Chromium trichloride
- Cas Number:
- 10025-73-7
- Molecular formula:
- Cl3Cr
- IUPAC Name:
- Chromium trichloride
- Test material form:
- solid: crystalline
Constituent 1
- Specific details on test material used for the study:
- Non disponible
- Radiolabelling:
- other: Dans certaines des études présentées seulement
Test animals
- Species:
- other: Différentes espèces utilisées selon l'étude décrite
- Strain:
- not specified
- Details on species / strain selection:
- Pas applicable
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- Pas applicable
Administration / exposure
- Route of administration:
- other: Voie d'administration différentes selon l'étude considérée
- Vehicle:
- not specified
- Details on exposure:
- Pas applicable
- Duration and frequency of treatment / exposure:
- Dépend de l'étude considérée
- No. of animals per sex per dose / concentration:
- Dépend de l'étude considérée
- Control animals:
- not specified
- Positive control reference chemical:
- Pas applicable
- Details on study design:
- Pas applicable
- Details on dosing and sampling:
- Pas applicable
- Statistics:
- Pas applicable
Results and discussion
- Preliminary studies:
- Pas applicable
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- Se référer au rapport Grevatt, 1998
- Details on distribution in tissues:
- Se référer au rapport Grevatt, 1998
- Details on excretion:
- Se référer au rapport Grevatt, 1998
Metabolite characterisation studies
- Metabolites identified:
- not specified
- Details on metabolites:
- Se référer au rapport Grevatt, 1998
Bioaccessibility (or Bioavailability)
- Bioaccessibility (or Bioavailability) testing results:
- Se référer au rapport Grevatt, 1998
Applicant's summary and conclusion
- Conclusions:
- Se référer au rapport Grevatt, 1998
- Executive summary:
Se référer au rapport Grevatt, 1998
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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