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EC number: 203-423-0 | CAS number: 106-68-3
A study was performed according to OECD Guideline 429 and Method 842 (EC) No. 440/2008 to assess the skin sensitisation potential of Methyl n-Amyl Ketone in the CBA/Ca strain mouse following topical application to the dorsal surface of the ear. Following a preliminary screening test in which no clinical signs of toxicity were noted at a concentration of 100%, this concentration was selected as the highest dose investigated in the main test of the Local Lymph Node Assay. Three groups, each of four animals, were treated with 50μI (25μI per ear) of the undiluted test item or the test item as a solution in acetone/olive oil 4:1 at concentrations of 50% or 25% v/v. A further group of four animals was treated with acetone/olive oil 4:1 alone. The Stimulation Index expressed as the mean radioactive incorporation for each treatment group ( 25%, 50% and 100%) divided by the mean radioactive incorporation of the vehicle control group were 0.44, 0.58 and 1.06 respectively. Indicating a negative result for all 3 dose groups. Therefore, the test item was considered to be a non-sensitiser under the conditions of the test does not need to be classified as a skin sensitizer in accordance with the criteria outlined in Annex I of the CLP Regulation (1272/2008/EC). This result is used for read-across to Ethyl Amyl Ketone.
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