Registration Dossier

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2004
Report Date:
2004

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
Qualifier:
according to
Guideline:
EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: particulate/powder

Test animals / tissue source

Species:
rabbit
Strain:
New Zealand White

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
cornea opacity score
Basis:
animal #1
Time point:
other:
Score:
0
Max. score:
80
Irritation parameter:
iris score
Basis:
animal #1
Time point:
other:
Score:
0
Max. score:
10
Irritation parameter:
conjunctivae score
Basis:
animal #1
Time point:
other:
Score:
8
Max. score:
20
Reversibility:
fully reversible within:
Irritation parameter:
conjunctivae score
Basis:
animal #1
Time point:
other:
Score:
2
Max. score:
20
Reversibility:
fully reversible within:
Irritation parameter:
conjunctivae score
Basis:
animal #1
Time point:
other:
Score:
0
Max. score:
20
Irritation parameter:
cornea opacity score
Basis:
animal #2
Time point:
other:
Score:
0
Max. score:
80
Irritation parameter:
iris score
Basis:
animal #2
Time point:
other:
Score:
5
Max. score:
10
Reversibility:
fully reversible within:
Irritation parameter:
iris score
Basis:
animal #2
Time point:
other:
Score:
0
Max. score:
10
Irritation parameter:
conjunctivae score
Basis:
animal #2
Time point:
other:
Score:
12
Max. score:
20
Reversibility:
fully reversible within:
Irritation parameter:
conjunctivae score
Basis:
animal #2
Time point:
other:
Score:
2
Max. score:
20
Reversibility:
fully reversible within:
Irritation parameter:
conjunctivae score
Basis:
animal #2
Time point:
other:
Score:
4
Max. score:
20
Reversibility:
fully reversible within:
Irritation parameter:
conjunctivae score
Basis:
animal #2
Time point:
other:
Score:
0
Max. score:
20
Irritation parameter:
cornea opacity score
Basis:
animal #3
Time point:
other:
Score:
0
Max. score:
80
Irritation parameter:
iris score
Basis:
animal #3
Time point:
other:
Score:
0
Max. score:
10
Irritation parameter:
conjunctivae score
Basis:
animal #3
Time point:
other:
Score:
8
Max. score:
20
Reversibility:
fully reversible within:
Irritation parameter:
conjunctivae score
Basis:
animal #3
Time point:
other:
Score:
2
Max. score:
20
Reversibility:
fully reversible within:
Irritation parameter:
conjunctivae score
Basis:
animal #3
Time point:
other:
Score:
0
Max. score:
20

Applicant's summary and conclusion