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Toxicological information

Genetic toxicity: in vitro

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Administrative data

Endpoint:
in vitro gene mutation study in bacteria
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
CICAD 29: Vanadium pentoxide and other inorganic vanadium compounds
Author:
Dr M. Costigan, Mr R. Cary, Dr S. Dobson
Year:
2001
Bibliographic source:
World Health Organization
Reference Type:
publication
Title:
Mutagenicity test data of existing chemical substances
Author:
JETOC
Year:
1996
Bibliographic source:
Japan Chemical Industry Ecology-Toxicology & Informaton Centre

Materials and methods

Principles of method if other than guideline:
No details
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Vanadium trichloride
EC Number:
231-744-6
EC Name:
Vanadium trichloride
Cas Number:
7718-98-1
Molecular formula:
Cl3V
IUPAC Name:
vanadium(3+) trichloride
Details on test material:
No details
Specific details on test material used for the study:
No details

Method

Target gene:
No details
Species / strainopen allclose all
Species / strain / cell type:
S. typhimurium TA 1535, TA 1537, TA 98, TA 100 and E. coli WP2
Details on mammalian cell type (if applicable):
No details
Additional strain / cell type characteristics:
not specified
Species / strain / cell type:
S. typhimurium TA 1538
Details on mammalian cell type (if applicable):
No details
Additional strain / cell type characteristics:
not specified
Metabolic activation:
with and without
Metabolic activation system:
No details
Test concentrations with justification for top dose:
Between 1 and 200 µg/ plate
Vehicle / solvent:
No details
Details on test system and experimental conditions:
No details
Rationale for test conditions:
No details
Evaluation criteria:
No details
Statistics:
No details

Results and discussion

Test resultsopen allclose all
Species / strain:
S. typhimurium TA 1535
Metabolic activation:
with and without
Genotoxicity:
negative
Cytotoxicity / choice of top concentrations:
not specified
Vehicle controls validity:
not specified
Untreated negative controls validity:
not specified
Positive controls validity:
not specified
Species / strain:
S. typhimurium TA 98
Metabolic activation:
with and without
Genotoxicity:
negative
Cytotoxicity / choice of top concentrations:
not specified
Vehicle controls validity:
not specified
Untreated negative controls validity:
not specified
Positive controls validity:
not specified
Species / strain:
S. typhimurium TA 100
Metabolic activation:
with and without
Genotoxicity:
negative
Cytotoxicity / choice of top concentrations:
not specified
Vehicle controls validity:
not specified
Untreated negative controls validity:
not specified
Positive controls validity:
not specified
Species / strain:
S. typhimurium TA 1537
Metabolic activation:
with and without
Genotoxicity:
not specified
Cytotoxicity / choice of top concentrations:
not specified
Vehicle controls validity:
not specified
Untreated negative controls validity:
not specified
Positive controls validity:
not specified
Species / strain:
S. typhimurium TA 1538
Metabolic activation:
with and without
Genotoxicity:
negative
Cytotoxicity / choice of top concentrations:
not specified
Vehicle controls validity:
not specified
Untreated negative controls validity:
not specified
Positive controls validity:
not specified
Species / strain:
E. coli WP2 uvr A
Metabolic activation:
with and without
Genotoxicity:
negative
Cytotoxicity / choice of top concentrations:
not specified
Vehicle controls validity:
not specified
Untreated negative controls validity:
not specified
Positive controls validity:
not specified
Additional information on results:
No details

Applicant's summary and conclusion

Conclusions:
One Ames test has been performed with vanadium trichloride. Negative results were obtained, in the presence and absence of metabolic activation, at concentrations between 1 and 200 μg/plate with Salmonella typhimurium strains TA98, TA100, TA1535, TA1537, and TA1538 and Escherichia coli WP2uvrA.
Executive summary:

One Ames test has been performed with vanadium trichloride. Negative results were obtained, in the presence and absence of metabolic activation, at concentrations between 1 and 200 μg/plate with Salmonella typhimurium strains TA98, TA100, TA1535, TA1537, and TA1538 and Escherichia coli WP2uvrA.