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EC number: 260-555-1 | CAS number: 57082-24-3
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from publication.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Fragrance raw materials monographs - CARYOPHYLLENE ACETATE.
- Author:
- D. L. J. Opdyke
- Year:
- 1 974
- Bibliographic source:
- Food and Cosmetics Toxicology, Vol. 12, Pg. 839, 1974.
- Reference Type:
- review article or handbook
- Title:
- Acute oral toxicity study of [1R-(1α,2α,5β,8β)]-4,4,8-trimethyltricyclo[6.3.1.02,5]dodecan-1-yl acetate (CAS no: 57082-24-3) in Rat.
- Author:
- Richard J. Lewis
- Year:
- 2 012
- Bibliographic source:
- Sax's Dangerous Properties of Industrial Materials, 12th Edition, 5 Volume Set, 2012.
- Reference Type:
- other: Authoritative database
- Title:
- Acute oral toxicity study of [1R-(1α,2α,5β,8β)]-4,4,8-trimethyltricyclo[6.3.1.02,5]dodecan-1-yl acetate (CAS no: 57082-24-3) in Rat
- Author:
- U.S. National Library of Medicine
- Year:
- 2 017
- Bibliographic source:
- ChemIDplus, A TOXNET DATABASE, Lite Browse Advanced, 2017.
- Reference Type:
- secondary source
- Title:
- Acute oral toxicity study of [1R-(1α,2α,5β,8β)]-4,4,8-trimethyltricyclo[6.3.1.02,5]dodecan-1-yl acetate (CAS no: 57082-24-3) in rat
- Author:
- U.S. Environmental Protection Agency, Chemistry Dashboard
- Year:
- 2 018
- Bibliographic source:
- Chemistry Dashboard, U.S. Environmental Protection Agency, 2018.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- Acute oral toxicity study of [1R-(1α,2α,5β,8β)]-4,4,8-trimethyltricyclo[6.3.1.02,5]dodecan-1-yl acetate (CAS no: 57082-24-3) in Rat.
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- [1R-(1α,2α,5β,8β)]-4,4,8-trimethyltricyclo[6.3.1.02,5]dodecan-1-yl acetate
- EC Number:
- 260-555-1
- EC Name:
- [1R-(1α,2α,5β,8β)]-4,4,8-trimethyltricyclo[6.3.1.02,5]dodecan-1-yl acetate
- Cas Number:
- 57082-24-3
- Molecular formula:
- C17H28O2
- IUPAC Name:
- [1R-(1α,2α,5β,8β)]-4,4,8-trimethyltricyclo[6.3.1.02,5]dodecan-1-yl acetate
- Details on test material:
- - IUPAC Name: [1R-(1α,2α,5β,8β)]-4,4,8-trimethyltricyclo[6.3.1.02,5]dodecan-1-yl acetate
- InChI: 1S/C17H28O2/c1-12(18)19-17-8-5-7-16(4,11-17)9-6-13-14(17)10-15(13,2)3/h13-14H,5-11H2,1-4H3/t13-,14+,16+,17-/m1/s1
- Smiles: CC(=O)O[C@@]12CCC[C@@](C)(CC [C@@H]3[C@@H]1CC3(C)C)C2
- Common Name of test material :Caryophyllene acetate
- Molecular formula:C17H28O2
- Molecular weight:264.4062 g/mol
- Substance type: Organic
- Physical state: Colorless slightly viscous liquid with a mild fruity woody odor.
Constituent 1
- Specific details on test material used for the study:
- - IUPAC Name: [1R-(1α,2α,5β,8β)]-4,4,8-trimethyltricyclo[6.3.1.02,5]dodecan-1-yl acetate
- InChI: 1S/C17H28O2/c1-12(18)19-17-8-5-7-16(4,11-17)9-6-13-14(17)10-15(13,2)3/h13-14H,5-11H2,1-4H3/t13-,14+,16+,17-/m1/s1
- Smiles: CC(=O)O[C@@]12CCC[C@@](C)(CC [C@@H]3[C@@H]1CC3(C)C)C2
- Common Name of test material :Caryophyllene acetate
- Molecular formula:C17H28O2
- Molecular weight:264.4062 g/mol
- Substance type: Organic
- Physical state: Colorless slightly viscous liquid with a mild fruity woody odor.
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- not specified
- Doses:
- 5000 mg/kg
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
- Details on study design:
- not specified
- Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No mortality was observed
- Mortality:
- No mortality was observed at 5000 mg/kg bw.
- Clinical signs:
- other: not specified
- Gross pathology:
- not specified
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Conclusions:
- The acute oral LD50 value was considered to be >5000 mg/kg bw, when rats were treated with [1R-(1α,2α,5β,8β)]-4,4,8-trimethyltricyclo[6.3.1.02,5]dodecan-1-yl acetate (CAS no: 57082-24-3) via oral route.
- Executive summary:
Acute oral toxicity study of[1R-(1α,2α,5β,8β)]-4,4,8-trimethyltricyclo[6.3.1.02,5]dodecan-1-yl acetate (CAS no: 57082-24-3) was conducted in rats at the concentration of 5000 mg/kg bw. No mortality was observed in treated rats at5000 mg/kg bw. Therefore, LD50 was considered to be >5000 mg/kg bw, when rats were treated with[1R-(1α,2α,5β,8β)]-4,4,8-trimethyltricyclo[6.3.1.02,5]dodecan-1-yl acetate via oral route.
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