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Ecotoxicological information

Toxicity to microorganisms

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Reference
Endpoint:
toxicity to microorganisms, other
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Remarks:
of read across substance
Justification for type of information:
Data for the target chemical is summarized based on the structurally similar read across chemicals
Reason / purpose:
read-across source
Reason / purpose:
read-across source
Qualifier:
according to
Guideline:
other: as mentioned below
Principles of method if other than guideline:
WoE report is based on two toxicity study of microorganisms for the test chemical :
Cell multiplication inhibition test was carried out to study the effects of test material on microorganism.
GLP compliance:
no
Analytical monitoring:
not specified
Vehicle:
not specified
Test organisms (species):
Pseudomonas putida
Details on inoculum:
No data available
Test type:
static
Water media type:
freshwater
Limit test:
no
Details on test conditions:
No data available
Reference substance (positive control):
not specified
Dose descriptor:
other: TT
Effect conc.:
220 mg/L
Nominal / measured:
not specified
Conc. based on:
test mat.
Basis for effect:
growth inhibition
Remarks on result:
other: Read across 1
Dose descriptor:
other: TT
Effect conc.:
62 mg/L
Nominal / measured:
not specified
Conc. based on:
test mat.
Basis for effect:
growth inhibition
Remarks on result:
other: Read across 2
Validity criteria fulfilled:
not specified
Conclusions:
The test chemical is likely to be toxic to microorganism in the dose range of 62-220 mg/l . Since the additional criteria mentioned in the CLP regulation related to BCF, biodegradability and Log Kow is not satisfied thus the substance has not been considered for aquatic toxicity classification.
Executive summary:

Data available for the functionally similar read across chemicals has been reviewed to determine the toxicity of microorganism of the test chemical.The studiesare as mentioned below:

For structurally similar read across , cell multiplication inhibition test was carried out to study the effects of test material on Pseudomonas putida. The threshold toxcity of test material on cell multiplication inhibition effect on Pseudomonas putida was observed to be 220 mg/L.

For another structurally similar read across , cell multiplication inhibition test was carried out to study the effects of test material on Pseudomonas putida. The threshold toxcity of test material on cell multiplication inhibition effect on Pseudomonas putida was observed to be 62 mg/L. Varied effect of test material on microorganisms were observed.

Description of key information

Toxicity to microorganisms:

Data available for the functionally similar read across chemicals has been reviewed to determine the toxicity of microorganism of the test chemical.The studiesare as mentioned below:

For structurally similar read across , cell multiplication inhibition test was carried out to study the effects of test material on Pseudomonas putida. The threshold toxcity of test material on cell multiplication inhibition effect on Pseudomonas putida was observed to be 220 mg/L.

For another structurally similar read across , cell multiplication inhibition test was carried out to study the effects of test material on Pseudomonas putida. The threshold toxcity of test material on cell multiplication inhibition effect on Pseudomonas putida was observed to be 62 mg/L. Varied effect of test material on microorganisms were observed.

Key value for chemical safety assessment

Additional information

Toxicity to microorganisms:

Data available for the functionally similar read across chemicals has been reviewed to determine the toxicity of microorganism of the test chemical.The studiesare as mentioned below:

For structurally similar read across , cell multiplication inhibition test was carried out to study the effects of test material on Pseudomonas putida. The threshold toxcity of test material on cell multiplication inhibition effect on Pseudomonas putida was observed to be 220 mg/L.

For another structurally similar read across , cell multiplication inhibition test was carried out to study the effects of test material on Pseudomonas putida. The threshold toxcity of test material on cell multiplication inhibition effect on Pseudomonas putida was observed to be 62 mg/L. Varied effect of test material on microorganisms were observed.