Registration Dossier

Ecotoxicological information

Toxicity to aquatic algae and cyanobacteria

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
toxicity to aquatic algae and cyanobacteria
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From August 21, 1989 to August 25, 1989
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Qualifier:
according to
Guideline:
other: DIN 38412 L9
GLP compliance:
no
Analytical monitoring:
no
Test organisms (species):
other: algae
Nominal and measured concentrations:
Concentrations tested: 100; 50; 25; 10; 5; 2.5 mg/L.
Key result
Duration:
72 h
Dose descriptor:
EC10
Effect conc.:
17.85 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
growth rate
Remarks on result:
other:
Remarks:
95% confidence intervals: 12.63; 25.22
Key result
Duration:
72 h
Dose descriptor:
EC50
Effect conc.:
142.78 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
growth rate
Remarks on result:
other:
Remarks:
95% confidence intervals: 72.09; 282.80
Key result
Duration:
72 h
Dose descriptor:
EC10
Effect conc.:
8.3 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
biomass
Remarks on result:
other:
Remarks:
95% confidence intervals: 3.89; 17.56
Key result
Duration:
72 h
Dose descriptor:
EC50
Effect conc.:
88.28 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
biomass
Remarks on result:
other:
Remarks:
95% confidence intervals: 28.37; 274.69
Conclusions:
Under the study conditions, the nominal 72 h ErC50 and ErC10 for growth rate were 142.78 mg/L and 17.85 mg/L, respectively. The nominal 72 h EbC50 and 72 h EbC10 for biomass were 88.28 mg/L and 8.3 mg/L, respectively.
Executive summary:

A study was conducted to determine the toxicity of the test substance to algae according to DIN 38412 L9. The nominal concentrations tested were: 100, 50, 25, 10, 5 and 2.5 mg/L. No analytical dose verification was conducted. Under the study conditions, the nominal 72 h ErC50 and ErC10 for growth rate were 142.78 mg/L and 17.85 mg/L, respectively. The nominal 72 h EbC50 and 72 h EbC10 for biomass were 88.28 mg/L and 8.3 mg/L, respectively (Hapke, 1989).

Description of key information

Key value for chemical safety assessment

EC50 for freshwater algae:
142.78 mg/L
EC10 or NOEC for freshwater algae:
17.85 mg/L

Additional information

A study was conducted to determine the toxicity of the test substance to algae according to DIN 38412 L9. The nominal concentrations tested were: 100, 50, 25, 10, 5 and 2.5 mg/L. No analytical dose verification was conducted. Under the study conditions, the nominal 72 h ErC50 and ErC10 for growth rate were 142.78 mg/L and 17.85 mg/L, respectively. The nominal 72 h EbC50 and 72 h EbC10 for biomass were 88.28 mg/L and 8.3 mg/L, respectively (Hapke, 1989).