Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 280-734-8 | CAS number: 83763-48-8
According to the results of the dermal penetration study (OECD method 428, GLP compliant, Klimisch 2), the dermal penetration rate of the registered substance 2-amino-4-hydroxyethylaminoanisole sulfate was 0.05%.
In the in-vitro basic toxicokinetics study, gastrointestinal permeability were studyied for the substance 2-amino-4-hydroxyethylaminoanisole sulfate using the TC-7 human intestinal epithelial cell line. A maximum amount of 0.712 ± 0.313 µg/cm2 of test substance was considered as biologically available.
Two in vitro studies were available to estimate the cutaneous absorption and oral bioavailability of the substance. The cutaneous absorption (in-vitro) of 1.5% 2 -Amino-4 -hydroxyethylamino anisole sulfate in a typical hair dye formulation in the presence of hydrogen peroxide and a reaction partner (1-Hydroxyethy1 4,5-Diamino Pyrazole Sulfate) was determined following methods according to the OECD Guideline 428 (Skin Absorption: In Vitro Method). This key study was performed with pigs skin in diffusion cell. Amount of test substance was quantified in rinsing solution 30 minutes after contact with test item and in the lower skin and the receptor fluid after 72h after test item exposure in oxidative formulations. The dermal absorption rate was 0.05%.
The second key study was performed to estimate the test substance bioavailability across the intestinal barrier in the A-B (apical to basolateral) Permeability assay using human intestinal epithelial cell line (TC-7). The uptake of the test substance from apical to basolateral cavity was analyzed by HPLC-MS/MS. A relative percent absorption of the test substance was indicated by the comparison with reference compounds. Interpretation of the results indicated highly permeability : Papp of 73.3 x10E-6 cm/s. Therefore, the gastrointestinal tract could be considered to be of 100%.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Close Do not show this message again