Titanium dihydride

Basic toxicokinetics

Administrative data

Endpoint:

basic toxicokinetics in vivo

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

2016

Reliability:

1 (reliable without restriction)

Data source

Reference

Reference Type:

publication

Title:

Unnamed

Year:

2016

Report date:

2016

Materials and methods

Objective of study:

distribution

toxicokinetics

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Refer to the full paper in material and methods section.
The objective of the study was to compare the effects of intravenous and oral administration of metal on the organism (male albino Wistar rats).

GLP compliance:

no

Test material

Specific details on test material used for the study:

Titanium(IV) citrate (C18H12NaO21Ti-7)

Test animals

Species:

rat

Strain:

Wistar

Sex:

male

Applicant's summary and conclusion

Conclusions:

The study made by the team of Golasik (2016) shows that titanium in ionic form has low oral bioavailability (3.8%) and is poorly absorbed into the circulation.

The Ti concentration 3 h after intravenous administration was about 100 times higher in serum, 10 times higher in kidneys and spleen, 8 times higher in liver than after the same time following 30-days repeated intragastric administration. The main organ for titanium deposition after administration of a soluble salt is kidney. This result might be related to the role of the kidneys with the elimination of this form of metal. The present results suggest that the exposure to ionic titanium should not result in excessive accumulation of metal in the organism.