Registration Dossier
Registration Dossier
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EC number: 700-150-3 | CAS number: 156572-81-5
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Vehicle:
- yes
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Daphnia magna Straus originates from a clone breeding of the German Federal Environmental Agency, department V 3.2, Berlin
- Test type:
- static
- Water media type:
- freshwater
- Total exposure duration:
- 48 h
- Test temperature:
- 20.6 to 21.4°C
- pH:
- 7.5-8.7
- Dissolved oxygen:
- 7.59 to 8.37 mg/L
- Nominal and measured concentrations:
- Nominal= 6.25, 12.5, 25,50,100, 200
- Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 14.08 mg/L
- Nominal / measured:
- nominal
- Remarks on result:
- other: 98% CL
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 6.25 mg/L
- Nominal / measured:
- nominal
- Duration:
- 48 h
- Dose descriptor:
- EC10
- Effect conc.:
- 12.15 mg/L
- Nominal / measured:
- nominal
- Validity criteria fulfilled:
- yes
- Conclusions:
- In a study performed to OECD 202, SLMI was found to have an EC50 (48h) of 14.1 mg/L
- Executive summary:
In a study performed to OECD 202, SLMI was found to have an EC50 (48h) of 14.1 mg/L
Reference
The recovery rates ranged from 97.3% to 120.0%. The highest decrease of the test concentration was -1.5%. According to the analytical results SLMI was stable during the test course.
Description of key information
In a study performed to OECD 202, SLMI was found to have an EC50 (48h) of 14.1 mg/L
In a study performed to EPA OPPTS 850.1010 the read across substance SCMI was found to have an EC50 of 257.86 mg/l (nominal concentration)
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 14.1 mg/L
Additional information
In a key study performed to OECD 202, SLMI was found to have an EC50 (48h) of 14.1 mg/L (nominal concentrations)
In a supporting study performed to EPA OPPTS 850.1010 on the read across material SCMI, an EC50 of 257.86 mg/l (95% C.I 194.51-341.83 mg/l) based on nominal concentrations was derived
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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