Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: No OECD guideline or GLP defined. Insufficient documentation.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 964
- Report date:
- 1964
Materials and methods
- Principles of method if other than guideline:
- Acute toxicity: inhalation
- GLP compliance:
- not specified
- Test type:
- other: Acute toxicity : inhalation
- Limit test:
- no
Test material
- Reference substance name:
- Not applicable
- Molecular formula:
- C19 H17 O4 P1
- IUPAC Name:
- Not applicable
Constituent 1
Test animals
- Species:
- sheep
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- Experiment was carried out in an 10 m³ room.
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- whole body
- Details on inhalation exposure:
- Experiment was carried out in a 10 m³ room with 2 shep/experiment.
In the first experiment 50g of DPK was sprayed twice in one hour.
In the second experiment 100g was sprayed once in one hour. - Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- Average concentration in first experiment : 0,37 mg/l DPK; average concentration in second experiment: 0,33 mg/l DPK
- Duration of exposure:
- 1 h
- Concentrations:
- Average concentration in first experiment : 0,37 mg/l DPK; average concentration in second experiment: 0,33 mg/l DPK
- No. of animals per sex per dose:
- 2 animals/dose
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- > 0.37 mg/L air
- Exp. duration:
- 1 h
Any other information on results incl. tables
No data on purity of the test substance.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- The LC50 was <0,37 mg/L air/1h (sheep).
- Executive summary:
The Inhalation study in sheep was executed with 50g, respectively 100g of the test substance in one hour.
These concentrations (0,37; respectively 0,33 mg/l DPK) caused temporarily irritations on mucous membrane.
No further symptoms of toxicity could be detected.
During the 6 week observation period after the experiment the animals showed no conspicuous behaviour.
The food consumption was good and the animals put on weight.
The inhalation toxicity of the test substance in sheep is low.
The LC50 was <0,37 mg/L air/1h.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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