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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: No OECD guideline or GLP defined. Insufficient documentation.
Cross-reference
Reason / purpose:
reference to same study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1964
Report Date:
1964

Materials and methods

Principles of method if other than guideline:
Acute toxicity: inhalation
GLP compliance:
not specified
Test type:
other: Acute toxicity : inhalation
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
sheep
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
Experiment was carried out in an 10 m³ room.

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
whole body
Details on inhalation exposure:
Experiment was carried out in a 10 m³ room with 2 shep/experiment.
In the first experiment 50g of DPK was sprayed twice in one hour.
In the second experiment 100g was sprayed once in one hour.
Analytical verification of test atmosphere concentrations:
yes
Remarks:
Average concentration in first experiment : 0,37 mg/l DPK; average concentration in second experiment: 0,33 mg/l DPK
Duration of exposure:
1 h
Concentrations:
Average concentration in first experiment : 0,37 mg/l DPK; average concentration in second experiment: 0,33 mg/l DPK
No. of animals per sex per dose:
2 animals/dose
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LC50
Effect level:
> 0.37 mg/L air
Exp. duration:
1 h

Any other information on results incl. tables

No data on purity of the test substance.

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification
Conclusions:
The LC50 was <0,37 mg/L air/1h (sheep).
Executive summary:

The Inhalation study in sheep was executed with 50g, respectively 100g of the test substance in one hour.

These concentrations (0,37; respectively 0,33 mg/l DPK) caused temporarily irritations on mucous membrane.

No further symptoms of toxicity could be detected.

During the 6 week observation period after the experiment the animals showed no conspicuous behaviour.

The food consumption was good and the animals put on weight.

The inhalation toxicity of the test substance in sheep is low.

The LC50 was <0,37 mg/L air/1h.