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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

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Mitschke (1987) reports the LC50 of diphenyl cresyl phospate in Danio rerio to be between 8.1 -11.5 mg/L over a 96 -hour period.

Ueda et al (1991) report the LC50 of diphenyl cresyl phosphate in Oryzia latipes to be 2.7 mg/L (24h), 1.7 mg/L (48h) and 1.3 mg/L (72h, 96h).

Aquatic invertebrates:

The 24 -hour EC50 for diphenyl cresyl phosphate in Daphnia magna was reported to be 3.7 mg/L (Japanese EA).

The toxicity and effects on reproduction of diphenyl cresyl phosphate were assessed in a 21 -day study in Daphnia magna. LC50 values declined from 4 mg/L at 24 hours to 0.35 mg/L at 14 days. EC50 values for reproduction were calculated to be 0.27 mg/L at 14 days and 0.31 mg/L at 21 days. NOEC and LOEC values were 0.12 and 0.38 mg/L, respectively (Japanese EA).


4 -hour IC50 values are reported for diphenyl cresyl phosphate to be 500 ug/L (Anabaena flos-aquae), 700 ug/L (Ankistrodesmus falcatus) and 1000 ug/L (Scenedesmus quadricauda) (Wong & Chau, 1984).

For Disflamoll DPK, the 72 -hour EC50 (growth) was calculated to be 0.55 mg/L. The 72- hour EC50 (biomass) was calculated to be 0.27 mg/L. Corresponding NOEC values were 0.20 and 0.093 mg/L, respectively (Weyers, 2006).

The 72 -hour EC50 (biomass) for diphenyl cresyl phosphate in Selenastrum capricornatum was calculated to be 0.99 mg/L; the NOEC in this study was found to be 0.55 mg/L (Ueda et al, 1991).


The 3 -hour LC50 of diphenyl cresyl phosphate to microorganisms is reported to be >10000 mg/L, which is greater than the limit of solubility of the substance (1.3 -2.6 mg/L); Kanne (1987)