Registration Dossier
Registration Dossier
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EC number: 940-273-1 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Formic acid causes mild skin irritation in an open skin irritation test according to RTECS.
A study to assess eye irritation does not need to be conducted (see 'justification for data waiving' in the relevant study record).
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin corrosion: in vitro / ex vivo
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- an in vitro skin irritation study does not need to be conducted because adequate data from an in vivo skin irritation study are available
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1992
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Open irritation test according to RTECS update 9001.
- GLP compliance:
- not specified
- Species:
- rabbit
- Type of coverage:
- open
- Preparation of test site:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 610 mg
- Duration of treatment / exposure:
- not specified
- Observation period:
- not specified
- Number of animals:
- not specified
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- ca. 1
- Reversibility:
- not specified
- Remarks on result:
- probability of mild irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- ca. 1
- Reversibility:
- not specified
- Remarks on result:
- probability of mild irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- ca. 2
- Reversibility:
- not specified
- Remarks on result:
- probability of mild irritation
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- ca. 1
- Reversibility:
- not specified
- Remarks on result:
- probability of mild irritation
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- ca. 1
- Reversibility:
- not specified
- Remarks on result:
- probability of mild irritation
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- ca. 2
- Reversibility:
- not specified
- Remarks on result:
- probability of mild irritation
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- According to RTECS formic acid causes mild skin irritation.
- Executive summary:
According to RTECS formic acid causes mild skin irritation.
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vitro / ex vivo
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the substance is classified as skin irritation and the available information indicates that it should be classified as eye irritation (Category 2)
Reference
Additional information
Justification for classification or non-classification
The available information indicates that the criteria are met for classification as irritating to the skin or irritating to eyes.
The multiconstituent substance Stabilisator for Cyanamid contains < 8 % formic acid. Therefore the substance is classified as Skin Irrit. 2 (H315) and Eye Irrit 2 (H319).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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