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Administrative data

Description of key information

SKIN IRRITATION 
minimally irritating to the skin (Draize Test; Hine et al., 1954); no labelling required.
EYE IRRITATION
mildly irritating to the eyes (Draize Test; Hine et al., 1954); no labelling required.

Key value for chemical safety assessment

Additional information

SKIN IRRITATION

In a primary dermal irritation study (Hine et al., 1954), p-tertiary-butyltoluene (purity not given) was tested according to the method of Draize et al (Draize Test; no further data).

p-tertiary-Butyltoluene was found to be only a mild rubefacient, with a skin irritation score of less than 0.5, according to the method of Draize. Erythema was more pronounced in the intact than in the scarified areas, and in only 1/6 animals was there evidence of edema at the site of  application. No further data. 

In this study, p-tertiary-butyltoluene is minimally irritating to the skin based on the Draize scores.

 

EYE IRRITATION

In a primary eye irritation study (Hine et al., 1954), p-tertiary-butyltoluene(purity not given) was tested according to the method of Draize et al (Draize Test; no further data).

The most consistent sign of eye irritation was a moderate to heavy discharge from the treated eyes. A slight chemosis was evident at the 24-hour point, but it had disappeared before the time of the 48-hour reading. According to Draize's method, the average total scores were 9.3 (1 h), 6.6 (24 h), and 4.0 (72 h) (maximum score = 110). According to the method of Carpenter and Smyth, the grade of irritation was less than 1. According to the authors, these classifications indicate only a moderate irritation of the conjunctivae.

In this study, 4-tertiary-butyltoluene) is mildly irritating to the eye based on the Draize scores.

Justification for classification or non-classification

There is no need to classify 4-tertiary-butyltoluene for skin irritation according to the Directive 67/548/EC or GHS criteria.

 

There is no need to classify 4-tertiary-butyltoluene for eye irritation according to the Directive 67/548/EC or GHS criteria.