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EC number: 202-675-9 | CAS number: 98-51-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- no data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data are given.
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicological studies on p-tertiary-butyltoluene.
- Author:
- Hine CH et al.
- Year:
- 1 954
- Bibliographic source:
- AMA Arch Ind Hyg Occup Med 9: 227-244.
Materials and methods
- Principles of method if other than guideline:
- No reference is cited for the method used. The test procedure is described very briefly in the publication.
- GLP compliance:
- no
- Remarks:
- pre-GLP study
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 4-tert-butyltoluene
- EC Number:
- 202-675-9
- EC Name:
- 4-tert-butyltoluene
- Cas Number:
- 98-51-1
- Molecular formula:
- C11H16
- IUPAC Name:
- 1-tert-butyl-4-methylbenzene
- Details on test material:
- - Name of test material (as cited in study report): p-tertiary-butyltoluene
- Physical state: liquid with distinct odour
- Analytical purity: no data
No further data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Long-Evans
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
male Long-Evans rats
- Weight at study initiation: 100 - 145 g
no further data
ENVIRONMENTAL CONDITIONS: no data
IN-LIFE DATES: no data
Administration / exposure
- Route of administration:
- other: intragastrically
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- no further details
- Doses:
- ca. 690, 1030, 1380, 1720, 2070 mg/kg bw (0.8, 1.2, 1.6, 2.0, 2.4 ml/kg bw)
- No. of animals per sex per dose:
- 10 males per group
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 10 days
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: no
- Other examinations performed: clinical signs, gross pathology and histopathology of decedents - Statistics:
- LD50 was calculated by the method of Miller LC and Tainter ML (1944). Estimation of the ED50 and Its Error by Means of Logarithmic-Probit Graph Paper. Proc Soc Exp Biol Med 57: 261-264.
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- ca. 1 550 mg/kg bw
- Remarks on result:
- other: Original value: LD50 = 1.8 +/- 0.14 ml/kg bw.
- Mortality:
- see table 2.
- Clinical signs:
- other: The rats receiving the higher dose levels were usually affected within 10 to 15 minutes; those receiving the lower doses were not appreciably affected until 30 minutes had passed. Signs of disturbance of the central nervous system predominated. At first t
- Gross pathology:
- The results of gross pathology are described in a generalized manner.
Gross lesions were present in the majority of animals which showed intoxication and survived for 10 or more hours and were invariably present in moribund animals which survived for 24 hours. These lesions consisted of cerebral edema, engorgement of the abdominal viscera, hyperemia of the .gastrointestinal tract and enlargement and yellowish discoloration of the liver. Slight irritation of the respiratory tract was also seen. - Other findings:
- - Histopathology:
The results of microscopic examination are presented for a battery of studies conducted with several species (rat, mouse and rabbit) and several routes of administration (oral, by inhalation, and dermal) and are presented here as a quotation.
“Microscopic examination of the tissues confirmed the extent of visceral involvement and disclosed a number of lesions in the central nervous system. The changes in the liver were principally due to fatty infiltration, which was either centrilobular or diffuse. In the tubular epithelium of the kidneys there were fine granular changes and moderate fatty deposits at the base. Pulmonary emphysema was conspicuous, and in some animals there was diffuse pulmonary edema and severe hemorrhage. All organs were hyperemic.
The lesions of the central nervous system […] may be summarized as follows: In cerebrum, cerebellum, and cord, there was diffuse edema of the white matter and occasionally acute necrosis, particularly in the corpus callosum and the cord. In many areas large vacuoles had formed which contained palely staining material of colloid-like appearance. Acute neuronal changes were present-swelling, vacuolation, and chromatolysis in the cortex, hippocampus, and cerebellum. In the spinal cord, beginning in the medulla oblongata, the nerve cells in the anterior gray columns frequently showed vacuolar changes of nuclei and occasionally complete chromatolysis. No lesions were seen in the sciatic nerves.
In occasional rats there was evidence of decreased numbers of erythrocytes and leucocytes in the peripheral blood. This occurred usually in animals that were severely intoxicated but survived for from 10 to 14 days. There was also occasional increase in the fat content of the bone marrow. However, no uniform abnormalities were seen with respect to the blood of rats.”
Any other information on results incl. tables
Table 2: mortality rates
Group |
No. of rats |
Dose level |
mortality |
|
[ml/kg bw] |
[mg/kg bw] |
|||
1 |
10 males |
0.8 |
ca. 690 |
2/10 |
2 |
10 males |
1.2 |
ca. 1030 |
3/10 |
3 |
10 males |
1.6 |
ca 1380 |
3/10 |
4 |
10 males |
2.0 |
ca. 1720 |
4/10 |
5 |
10 males |
2.4 |
ca. 2070 |
8/10 |
Conversion of ml into mg calculated with a density of 0.861 g/ml.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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