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Physical & Chemical properties

Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Experimental start date: 19 July 2017. Experimental completion date: 28 July 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
effusion method: vapour pressure balance
Specific details on test material used for the study:
Identification: Geniset D
Appearance/Physical state: white powder
Batch: 5434
Purity: 99.4%
Expiry date: 31 October 2018
Storage conditions: room temperature, in the dark
Key result
Temp.:
25 °C
Vapour pressure:
<= 0.004 Pa

Statistical data using an unweighted least squares method and the common logarithm of the vapor pressure at 25 °C (298 K) generated are shown in the following table:

Run Slope Standard Error
of slope		 Intercept Standard Error
of Intercept		 Log10 Vp
at 25 °C
Prelim  -4.11 x 103 106 9.84 0.278 -3.96
1  2.05 x 103 2.69 x 103 -6.92 -6.92 -2.41

Vapor Pressure at 25 °C from Preliminary run: 1.09 x 10-4 Pa

Vapor Pressure at 25 °C from Run 1: 3.94 x 10-3 Pa

The test item did not change in appearance under the conditions used in the determination.

Discussion

A fresh sample was used for the definitive test as most of the test item had volatised during the preliminary test.

No statistical analysis of the definitive test results was performed because the balance readings were too low and variable for a line of best fit to be applied. Instead it was considered more appropriate to impose a regression slope on a chosen data point to provide an estimate of the maximum value for the vapor pressure at 25 °C. This data point, occurring in Run 1, was the highest mass difference measured and gave the highest estimated vapor

pressure when a slope of -1500 K is imposed upon it.

The value of -1500 K is an in-house value and is the shallowest slope observed whilst determining the vapor pressure on a wide range of samples using the vapor pressure balance method. Extrapolation to 25 °C gave a vapor pressure of 3.94 x 10-3 Pa which has been taken as a maximum for this test item.

As a comparison, a result from the preliminary run was also generated based on data points that clearly showed a correlation.

Conclusions:
The vapor pressure of the test item by the balance method has been determined to be less than or equal to 3.94E-3 Pa at 25 °C (298 K).
Executive summary:

The vapor pressure of Geniset D has been determined to be less than or equal to 3.94 x 10-3 Pa at 25 °C (298 K) using the balance method, designed to be compatible with Method A.4 Vapour Pressure of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 104 of the OECD Guidelines for Testing of Chemicals, 23 March 2006.

Description of key information

The vapor pressure of Geniset D has been determined to be less than or equal to 3.94 x 10-3 Pa at 25 °C (298 K) using the balance method, designed to be compatible with Method A.4 Vapour Pressure of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 104 of the OECD Guidelines for Testing of Chemicals, 23 March 2006.

Key value for chemical safety assessment

Vapour pressure:
0.004 Pa
at the temperature of:
25 °C

Additional information