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Biodegradation in water

On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the percentage degradation of the test chemical Aluminum, 2-(1,3-dihydro-1,3-dioxo-2H-inden-2-ylidene)-1,2-dihydro-6,7-quinolinedisulfonate complexes can be expected to be range from 1.754 to 12.807%, respectively in 28 days. Thus, based on this, test chemical Aluminum, 2-(1,3-dihydro-1,3-dioxo-2H-inden-2-ylidene)-1,2-dihydro-6,7-quinolinedisulfonate complexes is considered to be not readily biodegradable in nature.

Additional information

Biodegradation in water

Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the biodegradability of the test chemicalAluminum, 2 -(1,3 -dihydro-1,3 -dioxo-2H-inden-2 -ylidene)-1,2 -dihydro-6,7-quinolinedisulfonate complexes.The studies are as mentioned below:

28-days Manometric respirometry testfollowing the OECD guideline 301F to determine the ready biodegradability of the test chemical. The test system included control, test item and reference item. The concentration of test and reference item ( Sodium Benzoate) chosen for both the study was 30 mg/L, while that of inoculum was 10 ml/l. ThOD (Theoretical oxygen demand) of test and reference item was determined by calculation. % Degradation was calculated using the values of BOD and ThOD for test item and reference item. The BOD28 value of test chemical was observed to be 0.022 mgO2sup>/mg. ThOD was calculated as 1.267 mgO2/mg. Accordingly, the % degradation of the test item after 28 days of incubation at 20 ± 1°C according to manometric respirometry test was determined to be 1.754 %.Based on the results, the test item, under the test conditions, was considered to be not readily biodegradable at 20 ± 1°C over a period of 28 days.

Another 28-days Manometric respirometry test following the OECD guideline 301F was conducted for determining the ready biodegradability of the test chemical. The test system included control, test item and reference item. The concentration of test and reference item ( Sodium Benzoate) chosen for both the study was 30 mg/L, while that of inoculum was 10 ml/l. ThOD (Theoretical oxygen demand) of test and reference item was determined by calculation. % Degradation was calculated using the values of BOD and ThOD for test item and reference item. The BOD28 value of test chemical was observed to be 0.188 mgO2sup>/mg. ThOD was calculated as 1.464 mgO2/mg. Accordingly, the % degradation of the test item after 28 days of incubation at 20 ± 1°C according to manometric respirometry test was determined to be 12.807 %.Based on the results, the test item, under the test conditions, was considered to be not readily biodegradable at 20± 1°C over a period of 28 days.

Additional biodegradation study was conducted for 28 days for evaluating the percentage biodegradability of test substance. The study was performed according to other guideline "Biodegradation test of a chemical substance using a microorganism etc." provided in "the Notice on the Test Method Concerning New Chemical Substances". Activated sludge was used as a test inoculum for the study. O2 uptake: Inoculum blank 5.7 mg, (Activated sludge + test substance) 7.2 m.DOC removal was corrected by purity and adsorption of activated sludge and HPLC degradation was corrected by adsorption of activated sludge, because the recovery rate was 83 % in (activated sludge + test substance) system.The percentage degradation of test substance was determined to be 3% by using O2 consumption, DOC removal, Test mat. analysis and HPLC parameter in 28 days.Thus, based on percentage degradation, test chemical is considered to be not readily biodegradable in nature.

On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the percentage degradation of the test chemical Aluminum, 2-(1,3-dihydro-1,3-dioxo-2H-inden-2-ylidene)-1,2-dihydro-6,7-quinolinedisulfonate complexes can be expected to be range from 1.754 to 12.807%, respectively in 28 days. Thus, based on this, test chemical Aluminum, 2-(1,3-dihydro-1,3-dioxo-2H-inden-2-ylidene)-1,2-dihydro-6,7-quinolinedisulfonate complexes is considered to be not readily biodegradable in nature.