Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

skin irritation / corrosion, other
Classification based on calculation rules for mixtures of the CLP Regulation
Type of information:
calculation (if not (Q)SAR)
Adequacy of study:
key study
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
accepted calculation method

Data source

Reference Type:
other: Guidance
Guidance on the Application of the CLP Criteria - Guidance to Regulation (EC) No 1272/2008 on classification, labelling and packaging (CLP) of substances and mixtures
Bibliographic source:

Materials and methods

Test guideline
no guideline required
Principles of method if other than guideline:
Classification based on calculation rules for mixtures of the CLP Regulation

Test material

Constituent 1
Reference substance name:
Carrot, ext.
EC Number:
EC Name:
Carrot, ext.
Cas Number:
Molecular formula:
Not applicable
(2E)-3,7-dimethylocta-2,6-dien-1-yl acetate; (3R,3aS,8aR)-6,8a-dimethyl-3-(propan-2-yl)-1,2,3,3a,4,5,8,8a-octahydroazulen-3a-ol; (4S)-1-methyl-4-(6-methylhepta-1,5-dien-2-yl)cyclohex-1-ene; 2,6,6-trimethylbicyclo[3.1.1]hept-2-ene; 4-methylidene-1-(propan-2-yl)bicyclo[3.1.0]hexane

Results and discussion

In vivo

Irritation parameter:
other: classification
Remarks on result:
other: skin irritant category 2

Applicant's summary and conclusion

Interpretation of results:
Category 2 (irritant) based on GHS criteria
Executive summary:

The NCS is composed of several identified constituents and in that, it can be considered as a mixture according to the definition of the CLP Regulation.

The decision logic for classification of mixtures from the ECHA Guidance on the Application of the CLP Criteria (2017) was used to determine the skin irritation/corrosion hazard of the registered substance. The decision of classification as skin irritant was based on existing data on constituents (additivity principles): the registered substance has more than 10% (w/w) of its constituents classified as Skin irritant Category 2 (alpha-pinene, beta-pinene, geranyl acetate, beta-myrcene, beta-bisabolene, caryophylene oxide, linalool and geraniol) therefore it should be classified as a skin irritant Category 2 without further testing according to the rules for classification of mixtures of Regulation (EC) No 1272/2008.