Registration Dossier
Registration Dossier
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EC number: 204-977-6 | CAS number: 130-15-4
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- not specified
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The use of secondary sources of data is acceptable when they are based on a critical evaluation of peer-reviewed data and a consequent selection of a reliable and representative values for the properties under investigation.
The study cited was taken from the HSDB and detailed as being peer reviewed and from a authoritative data source and accordingly is considered adequate for assessment as part of a weight of evidence approach. - GLP compliance:
- not specified
- Type of method:
- other: unknown
- Partition coefficient type:
- octanol-water
- Type:
- log Pow
- Partition coefficient:
- 1.71
- Remarks on result:
- other: No temperature provided.
- Conclusions:
- The test substance partition coefficient (log Pow) was determined to be 1.71 based on a result taken from peer reviewed handbook data.
- Endpoint:
- partition coefficient
- Type of information:
- not specified
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Authoritative database
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The authoritative database form the Institute for Occupational Safety and Health of the German Social Accident Insurance (GESTIS database) is regarded as reliable literature source and was taken into account in this weight of evidence approach. The GESTIS database reports the partition coefficient as 1.71.
- GLP compliance:
- not specified
- Type of method:
- other: unknown
- Partition coefficient type:
- octanol-water
- Type:
- log Pow
- Partition coefficient:
- 1.71
- Remarks on result:
- other: No temperature provided
- Conclusions:
- The test substance partition coefficient (log Pow) was determined to be 1.71 based on a result taken from the GESTIS database.
- Endpoint:
- partition coefficient
- Type of information:
- not specified
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Deviations:
- not specified
- Principles of method if other than guideline:
- The use of secondary sources of data is acceptable when they are based on a critical evaluation of peer-reviewed data and a consequent selection of a reliable and representative values for the properties under investigation.
The study cited was taken from the Japan NITE database which details that an OECD 107 study was conducted on the substance and accordingly is considered adequate for assessment as part of a weight of evidence approach. - GLP compliance:
- not specified
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
- Type:
- log Pow
- Partition coefficient:
- 1.77
- Remarks on result:
- other: No temperature provided.
- Conclusions:
- The test substance partition coefficient (log Pow) was determined to be 1.77 based on a result taken from a secondary source.
Referenceopen allclose all
Description of key information
A total of two Log Kow values (1.71 and 1.77) are available for this substance based on reliable handbook/secondary source data. The value of 1.77 is selected as the key value for chemical safety assessment as is the most conservative. The method and some experimental details for this test are also available (as well as the test temperature).
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 1.77
- at the temperature of:
- 25 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
