Registration Dossier
Registration Dossier
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EC number: 208-736-6 | CAS number: 540-10-3
Melting point / freezing point
Administrative data
Link to relevant study record(s)
- Endpoint:
- melting point/freezing point
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Principles of method if other than guideline:
- Method not specified
- GLP compliance:
- no
- Melting / freezing pt.:
- 54 °C
- Atm. press.:
- ca. 1 013 hPa
- Endpoint:
- melting point/freezing point
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: peer-reviewed literature
- Principles of method if other than guideline:
- Method not specified
- GLP compliance:
- no
- Melting / freezing pt.:
- >= 52 - <= 56 °C
- Atm. press.:
- ca. 1 013 hPa
- Endpoint:
- melting point/freezing point
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Principles of method if other than guideline:
- Method not specified
- GLP compliance:
- no
- Melting / freezing pt.:
- 54 °C
- Atm. press.:
- ca. 1 013 hPa
- Endpoint:
- melting point/freezing point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Certificate of Analysis
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- other: European Pharmacopoeia 2.2.15. Melting Point - Open Capillary Method
- GLP compliance:
- no
- Type of method:
- other: Open Capillary Method
- Key result
- Melting / freezing pt.:
- ca. 54.3 °C
- Atm. press.:
- ca. 1 013 hPa
Referenceopen allclose all
Pressure was not reported. It is assumed that melting point was tested at ambient conditions.
Pressure was not reported. It is assumed that melting point was tested at ambient conditions.
Pressure was not reported. It is assumed that melting point was tested at ambient conditions.
Lower measured melting point: 46.0 °C
Higher measured melting point: 58.0 °C
The pressure was not reported in the certificate of analysis; melting point measured according to open capillary method, therefore ambient conditions can be assumed (pressure ca. 1013 hPa).
Description of key information
Melting point = 54.3 °C (Eur. Ph. 2.2.15, Open Capillary Method)
Pressure not reported, assumed to be normal pressure (1013 hPa).
Key value for chemical safety assessment
- Melting / freezing point at 101 325 Pa:
- 54.3 °C
Additional information
Melting point values from three reliable sources have been chosen as supporting information:
54 °C (Handbook of Chemistry and Physics – 86th Edition 2005-2006, 2005)
54 °C (The Merck Index - An Encyclopedia of Chemicals and drugs - Ninth Edition, 1976)
52-56 °C (Souto et al., J Microencapsul, 2005)
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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