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Physical & Chemical properties

Vapour pressure

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Administrative data

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
17. Oct. 2016 - 26. Apr. 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
GLP compliance:
yes (incl. QA statement)
Type of method:
effusion method: Knudsen cell
Specific details on test material used for the study:
SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: 5-10-A
- Expiration date of the lot/batch: 19. Oct. 2018
- Purity test date:19. Oct. 2015

STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: stored in a tightly closed vessel at room temperature under dry conditions in the dark
- Stability under test conditions: assumed stable
- Solubility and stability of the test substance in the solvent/vehicle: n/a
- Reactivity of the test substance with the solvent/vehicle of the cell culture medium: none expeced

TREATMENT OF TEST MATERIAL PRIOR TO TESTING
none
Key result
Temp.:
ca. 20 °C
Vapour pressure:
>= 0 - <= 0 Pa
Remarks on result:
other: calculated results
Test no.:
#4
Temp.:
ca. 348.2 K
Vapour pressure:
ca. 0.001 Pa
Remarks on result:
other: calculated for molecular mass of 891 g/mol
Test no.:
#5
Temp.:
ca. 363.2 K
Vapour pressure:
ca. 0.001 Pa
Remarks on result:
other: calculated for molecular mass of 891 g/mol
Test no.:
#6
Temp.:
ca. 378.2 K
Vapour pressure:
ca. 0.002 Pa
Remarks on result:
other: calculated for molecular mass of 891 g/mol
Test no.:
#7
Temp.:
ca. 393.2 K
Vapour pressure:
ca. 0.002 Pa
Remarks on result:
other: calculated for molecular mass of 891 g/mol
Test no.:
#4
Temp.:
ca. 348.2 K
Vapour pressure:
ca. 0.001 Pa
Remarks on result:
other: calculated for molecular mass of 1065 g/mol
Test no.:
#5
Temp.:
ca. 363.2 K
Vapour pressure:
ca. 0.001 Pa
Remarks on result:
other: calculated for molecular mass of 1065 g/mol
Test no.:
#6
Temp.:
ca. 378.2 K
Vapour pressure:
ca. 0.002 Pa
Remarks on result:
other: calculated for molecular mass of 1065 g/mol
Test no.:
#7
Temp.:
ca. 393.2 K
Vapour pressure:
ca. 0.002 Pa
Remarks on result:
other: calculated for molecular mass of 1065 g/mol
Key result
Temp.:
ca. 25 °C
Vapour pressure:
>= 0 - <= 0 Pa
Remarks on result:
other: calculted results
Conclusions:
The Range of vapour pressure at 20 °C is 6.95 * 10E-05 - 7.60 *10E-05
and for 25 °C 8.71 * 10E-05 - 9.52 *10E-05
Executive summary:

The vapour pressure of Nomcort SG was determined following EU A.4 using the effusion method (weight loss).

Vapour pressure was examined at seven different temperatures. Four temperatures could be evaluated as they showed reproducible weitht loss. For these temperatures, 1/T was plotted against log (P).

Table 1: Vapour pressures (Effustion method) for a molecular mass of 891 g/mol

 Experiment T Mean P  Stand. Dev. P  RSD P 
 No. K  Pa  Pa  % 
 4 348.2  6.10E-04  5.92E-05  9.7% 
5  363.2  1.05E-03  1.52E-04  14.5% 
 6 378.2  1.65E-03  2.15E-04  13 .0% 
 7 393.2  2.20E-03  1.19E-04  5.4% 

Table 2: Vapour pressures (Effustion method) for a molecular mass of 1065 g/mol

 Experiment T Mean P  Stand. Dev. P  RSD P 
 No. K  Pa  Pa  % 
 4 348.2  5.58E-04  5.41E-05  9.7% 
5  363.2  9.60E-04  1.39E-04  14.5% 
 6 378.2  1.51E-03  1.97E-04  13 .0% 
 7 393.2  2.01E-03  1.09E-04  5.4% 

The fraphs 1/T vs. log (P) show straight lines with a correlation coefficient (r) of - 0.9951.

For the test item Nomcort SG, the following ranges of the vapour pressure at 20 °C and at 25 °C were calculated from the regression equation and the limit values of the molecular mass of the test item :

Vapour pressure at 20 °C: 6.95 * 10E-05 - 7.60 *10E-05

Vapour pressure at 25 °C: 8.71 * 10E-05 - 9.52 *10E-05

Description of key information

Guideline study using effusion method (weight loss)

Key value for chemical safety assessment

Vapour pressure:
0 Pa
at the temperature of:
20 °C

Additional information