Registration Dossier
Registration Dossier
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EC number: 244-942-2 | CAS number: 22374-89-6
Endpoint summary
Administrative data
Description of key information
The study need not be conducted because the substance is a strong acid (pH<=2.0) or strong base (pH=> 11.5).The experimental pH of 1-methyl-3-phenylpropylamine (CAS no.: 22374-89-6) was 11.6.Hence this endpoint, skin sensitization was considered for waiver.
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the substance is a strong acid (pH ≤2.0) or base (pH =>11.5)
- Justification for type of information:
- The study need not be conducted because the substance is a strong acid (pH<=2.0) or strong base (pH=> 11.5).The experimental pH of 1-methyl-3-phenylpropylamine (CAS no.: 22374-89-6) was 11.6.Hence this endpoint, skin sensitization was considered for waiver.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
The study need not be conducted because the substance is a strong acid (pH<=2.0) or strong base (pH=> 11.5).The experimental pH of 1-methyl-3-phenylpropylamine (CAS no.: 22374-89-6) was 11.6.Hence this endpoint, skin sensitization was considered for waiver.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
The study need not be conducted because the substance is a strong acid (pH<=2.0) or strong base (pH=> 11.5).The experimental pH of 1-methyl-3-phenylpropylamine (CAS no.: 22374-89-6) was 11.6.Hence this endpoint, skin sensitization was considered for waiver.
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