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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Environmental fate & pathways

Endpoint summary

Administrative data

Description of key information

Bioaccumulation: aquatic / sediment

BCFBAF model of Estimation Programs Interface was used to predict the bioconcentration factor (BCF) of test chemical 1-methyl-3-phenylpropylamine (CAS No. 22374 -89 -6). The bioconcentration factor (BCF) of 1-methyl-3-phenylpropylamine was estimated to be 11.64 L/kg whole body w.w (at 25 deg C) which does not exceed the bio concentration threshold of 2000, indicating that the chemical 1-methyl-3-phenylpropylamine is not expected to bioaccumulate in the food chain.

Additional information

Bioaccumulation: aquatic / sediment

Various predicted data for the target compound 1-methyl-3-phenylpropylamine (CAS No. 22374-89-6) and supporting weight of evidence study for its structurally and functionally similar read across substance were reviewed for the bioaccumulation end point which are summarized as below:

 

In aprediction done using theBCFBAF Programof Estimation Programs Interface was used to predict the bioconcentration factor (BCF) of test chemical 1-methyl-3-phenylpropylamine (CAS No. 22374 -89 -6). The bioconcentration factor (BCF) of 1-methyl-3-phenylpropylamine was estimated to be 11.64 L/kg whole body w.w (at 25 deg C).

 

In an another prediction done by using Bio-concentration Factor module(2017), theBio-concentration Factor (BCF) over the pH scale of the test substance 1-methyl-3-phenylpropylamine (CAS no. 22374 -89 -6) was estimated to be 1, 5.01, 18.5, 25.5, 26.4 and 26.5 at pH range 1-9, 10, 11, 12, 13 and 14, respectively.

 

Bioconcentration Factor (BCF) of test chemical 1-methyl-3-phenylpropylamine was estimated using Chemspider database(2017). The bioconcentration factor of test substance 1-methyl-3-phenylpropylamine was estimated to be 1 at pH both 5.5 and 7.4, respectively.

 

Another predicted data was estimated usingSciFinder database (2017) was used for predicting the bioconcentration factor (BCF) of test chemical 1-methyl-3-phenylpropylamine (CAS No. 22374 -89 -6). The bioconcentration factor (BCF) of 1-methyl-3-phenylpropylamine was estimated to be 1 and 5.83 at pH range 1-9 & 10, respectively (at 25 deg C).

 

In a supporting weight of evidence study from authoritative database (2017) for the test item, bioaccumulation experiment in fish was conducted for estimating the BCF (bioaccumulation factor) value of test chemical. The bioaccumulation factor (BCF) value was calculated using a logKow of 1.76 and a regression-derived equation. The estimated BCF (bioaccumulation factor) value of of test chemical was determined to be 7.0 dimensionless.

 

For the test chemical,bioaccumulation study in Lepomis macrochirus (bluegill fish) was conducted for determining the BCF (bioaccumulation factor) value of test chemical (authoritative database, 2017).The study was performed under flow through conditions. The BCF (bioaccumulation factor) value of test substance was determined to be 35 dimensionless.

 

On the basis of above results for target chemical 1-methyl-3-phenylpropylamine (from modelling databases, 2017), it can be concluded that the BCF value of test substance 1-methyl-3-phenylpropylamine ranges from 1 –26.5 which does not exceed the bioconcentration threshold of 2000, indicating that the chemical 1 -methyl-3 -phenylpropylamine is not expected to bioaccumulate in the food chain.