Registration Dossier

Administrative data

Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
from 12 June 2017 to 20 September 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2017
Report Date:
2017

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to
Guideline:
EU Method A.4 (Vapour Pressure)
Version / remarks:
2009
Deviations:
no
Qualifier:
according to
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Version / remarks:
2006
Deviations:
no
Qualifier:
according to
Guideline:
EPA OPPTS 830.7950 (Vapor Pressure)
Version / remarks:
1996
Deviations:
no
GLP compliance:
yes
Type of method:
effusion method: isothermal thermogravimetry

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid
Remarks:
paste
Details on test material:
Name as cited in report: DDDA TEA salt
Physical appearance: beige to pale yellow paste
Storage conditions: at room temperature
Specific details on test material used for the study:
Melting point: 26.2°C.

Results and discussion

Vapour pressureopen allclose all
Key result
Temp.:
20 °C
Vapour pressure:
<= 0.003 Pa
Key result
Temp.:
25 °C
Vapour pressure:
<= 0.005 Pa

Any other information on results incl. tables

Table: Results of the isothermal TGA analysis (test item)

 

Temperature
[°C]

Weight loss
[µg/min]

vT
[g/cm2/h]

log vT

log PT

PT
[Pa]

110

7.93611

9.47 E-4

-3.02

1.17

15

 

10.8284

1.29 E-3

-2.89

1.34

22

 

9.38273

1.12 E-3

-2.95

1.26

18

120

15.1747

1.81 E-3

-2.74

1.53

34

 

18.0437

2.15 E-3

-2.67

1.62

42

 

15.1992

1.81 E-3

-2.74

1.53

34

130

27.5639

3.29 E-3

-2.48

1.85

71

 

30.7645

3.67 E-3

-2.44

1.91

82

 

29.1819

3.48 E-3

-2.46

1.88

77

140

44.6395

5.33 E-3

-2.27

2.12

1.3 E2

 

49.0498

5.85 E-3

-2.23

2.17

1.5 E2

 

48.0555

5.74 E-3

-2.24

2.16

1.4 E2

 

Applicant's summary and conclusion

Conclusions:
The vapour pressure of the substance at 20°C was determined to be ≤ 2.9E-3 Pa.
The vapour pressure of the substance at 25°C was determined to be ≤ 5.5E-3 Pa.
Executive summary:

The vapour pressure of the substance was determined using the isothermal thermogravimetric effusion method in a GLP study according to EC A.4, OECD 104 and OPPTS 830.7950.

A vapour pressure curve was constructed from duplicate measurements at 110°C, 120°C, 130°C and 140°C. The vapour pressure of the substance at 20°C and 25°C was determined by extrapolation to be 2.9E-3 Pa and 5.5E-3 Pa, resp.

Since the weight losses of the test item were obtained with a temperature program of above the melting temperature of the test item, the vapour pressure of the test item could be slightly overestimated. The vapour pressure of the substance at 20°C and 25°C was therefore reported as ≤ 2.9E-3 Pa and ≤ 5.5E-3 Pa, resp.