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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Only secondary literature available. Peer-reviewed database.

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1969
Reference Type:
secondary source
Title:
Toxicological Evaluations Vol. 13
Author:
BG Chemie
Year:
1998
Bibliographic source:
Springer-Verlag Berlin Heidelberg, ISBN 3-540-62658-1

Materials and methods

Principles of method if other than guideline:
0.1 ml TS was instilled into the conjunctival sac of the rabbit eye either neat or as a 10, 5 or 1% solution in sesame oil. The eyes were examined 1, 3, 7, 24, 48 and 72 hours and 6 days after instillation.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Fluorobenzene
EC Number:
207-321-7
EC Name:
Fluorobenzene
Cas Number:
462-06-6
Molecular formula:
C6H5F
IUPAC Name:
fluorobenzene

Test animals / tissue source

Species:
rabbit

Test system

Vehicle:
other: sesame oil
Amount / concentration applied:
- Amount applied: 0.1 ml
- Concentration: undiluted, 10, 5 or 1%
Observation period (in vivo):
6 days
Number of animals or in vitro replicates:
5

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
cornea opacity score
Basis:
mean
Time point:
24/48/72 h
Score:
> 0
Reversibility:
not specified
Remarks on result:
other: after application of 0.1 ml undiluted TS
Irritation parameter:
conjunctivae score
Basis:
mean
Time point:
24/48/72 h
Score:
> 0
Reversibility:
not specified
Remarks on result:
other: after application of 0.1 ml undiluted TS
Irritant / corrosive response data:
The neat substance caused redness and severe cloudy swelling of the conjunctiva in all test animals. In addition 4 out of 5 rabbits showed slight clouding of the cornea (no data on reversibility). The dilutions had no irritant effects. Fluorobenzene was classified as severely irritating to the eye.

Any other information on results incl. tables

The neat substance caused redness and severe cloudy swelling of the conjunctiva in all test animals. In addition 4 out of 5 rabbits showed slight clouding of the cornea (no data on reversibility). The dilutions had no irritant effects. Fluorobenzene was classified as severely irritating to the eye.

Applicant's summary and conclusion

Interpretation of results:
highly irritating
Remarks:
Migrated information