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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2 to 3 March 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Version / remarks:
2004
GLP compliance:
yes (incl. certificate)
Remarks:
Swiss Federal Office of Public Health, Bern, Switzerland
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
1.94
Temp.:
20 °C
Remarks on result:
other: pH not measured or not reported.

The R² fit of the calibration curve used was 0.986. The deviations of calculated Log POW-values from actual ones were 8.8 % at maximum. This reflects the linear correlation between the logarithms of the capacity factors of the HPLC system and the Log POW-values of the reference items in the applied range of 0.5 to 3.4.

 

The following table summarizes the results obtained for the test item.

 

Test Item

Retention Time [min]

Log k'

Log POW

Mean

Overall Mean

Solution 1

1strun

2.700

0.0625

1.951

1.95

1.94 ± 0.00

2ndrun

2.700

0.0580

1.943

Solution 2

1strun

2.700

0.0580

1.943

1.94

2ndrun

2.700

0.0580

1.943

 

Conclusion

During this study, the partition coefficient (n-octanol/water) of the test item was determined using the HPLC method. The Log POW-value of the test item was found to be 1.94.

Conclusions:
A partition coefficient value of 1.94 (at 20 °C) was determined for the test substance according to OECD 117.

Description of key information

Log Kow: 1.94 at 20 °C (OECD Guideline 117, HPLC method)

Key value for chemical safety assessment

Log Kow (Log Pow):
1.94
at the temperature of:
20 °C

Additional information