Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 219-194-5 | CAS number: 2385-77-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Remarks:
- The test substance (Citronellal; CAS 106-23-0) represents the racemate of the registered substance (R)-3,7-dimethyloct-6-enal (CAS 2385-77-5).
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data available as short summary from a secondary source beeing cited in a peer-reviewed publication
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- Acute oral toxicity in rats; dermal toxicity in rabbits (2-Isopropyl-5- methyl-2-hexenal; Citronellol; Citronellal; Rhodinol). Unpublished report Nos. 73–197,73–88,73–190,73–150 from MB Research Laboratories, Inc., Perkasie, Pennsylvania, USA. Submitted
- Author:
- Moreno, O.M.
- Year:
- 1 973
- Bibliographic source:
- cited in: Opdyke DL; Monographs on Fragrance Raw Materials. Citronellal; Food Cosmet Toxicol 13 (SUPPL): 755 (1975).
- Reference Type:
- secondary source
- Title:
- Acute oral toxicity in rats; dermal toxicity in rabbits (2-Isopropyl-5- methyl-2-hexenal; Citronellol; Citronellal; Rhodinol). Unpublished report Nos. 73–197,73–88,73–190,73–150 from MB Research Laboratories, Inc., Perkasie, Pennsylvania, USA. Submitted
- Author:
- Moreno, O.M.
- Year:
- 1 973
- Bibliographic source:
- cited in: RIFM-FEMA Database CAS 106-23-0 RIFM ID 156 FEMA 2307
- Reference Type:
- secondary source
- Title:
- Moreno, O.M. (1978) Acute oral toxicity in rats; acute dermal toxicity in rabbits (3,7-Dimethyl- 6-octenoic acid). Unpublished report No. MB 78-2628 from MB Research Laboratories, Inc., Spinnerstown, Pennsylvania, USA. Submitted to WHO by the Flavor and E
- Author:
- Moreno, O.M.
- Year:
- 1 978
- Bibliographic source:
- WHO FOOD ADDITIVES SERIES: 52 Safety evaluation of certain food additives and contaminants Prepared by the Sixty-first meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- no data
- GLP compliance:
- not specified
- Test type:
- other: no data
Test material
- Reference substance name:
- Citronellal
- EC Number:
- 203-376-6
- EC Name:
- Citronellal
- Cas Number:
- 106-23-0
- Molecular formula:
- C10H18O
- IUPAC Name:
- 3,7-dimethyloct-6-enal
- Details on test material:
- - Name of test material (as cited in study report): citronellal
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Duration of exposure:
- no data
- Doses:
- 2500, 5000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 2 500 - < 5 000 mg/kg bw
- Mortality:
- 3/5 at 5000 mg/kg; 0/5 at 2500 mg/kg
- Clinical signs:
- other: 5000 mg/kg: lethargy reported in 1/5
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.