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Diss Factsheets
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EC number: 228-244-5 | CAS number: 6192-13-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Particle size distribution (Granulometry)
Administrative data
Link to relevant study record(s)
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 30 June 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: European Commission Technical Guidance Document EUR 20268 'Determination of Particle Size Distribution, Fibre Length and Diameter Distribution of Chemical Substances’
- Version / remarks:
- 2002
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- sieving
- Type of particle tested:
- primary particle
- Type of distribution:
- mass based distribution
- Key result
- Remarks on result:
- other: The percentage of test material having an inhalable particle size of less than 100 μm was determined to be 7.8 %.
- Conclusions:
- Under the conditions of the study the percentage of test material having an inhalable particle size of less than 100 μm was determined to be 7.8%. The test material has been considered to be essentially non-inhalable.
- Executive summary:
The particle size distribution of the test material was determined in accordance with the standardised guideline EUR 20268 under GLP conditions using the sieving method.
An aliquot (14.25 g) of test material was added to a 100 μm sieve fitted onto a receiver pan of known mass. A lid was then secured onto the sieve and the assembled apparatus placed on a sieve shaker for a period of approximately 30 minutes. Following the shaking period, the mass of the receiver pan and collected test material was recorded and the percentage of test material with a particle size less than 100 μm calculated. As the percentage of the test item that passed through the 100 μm sieve was less than 10%, further testing was not required.
Under the conditions of the study the percentage of test material having an inhalable particle size of less than 100 μm was determined to be 7.8%. The test material has been considered to be essentially non-inhalable.
Reference
Table 1: Table to show the results of the sieving procedure
Measurement |
Result |
Mass of test material transferred to sieve (W1) |
14.25 g |
Mass of test material passed through sieve (W3 – W2) |
1.11 g |
Percentage of test material less than 100 μm |
7.79 % |
Description of key information
Fox, 2017
Under the conditions of the study the percentage of test material having an inhalable particle size of less than 100 μm was determined to be 7.8%. The test material has been considered to be essentially non-inhalable.
Additional information
The particle size distribution of the test material was determined in accordance with the standardised guideline EUR 20268 under GLP conditions using the sieving method. The study was awarded a reliability score of 1 in accordance with the criteria set forth by Klimisch et al. (1997).
An aliquot (14.25 g) of test material was added to a 100 μm sieve fitted onto a receiver pan of known mass. A lid was then secured onto the sieve and the assembled apparatus placed on a sieve shaker for a period of approximately 30 minutes. Following the shaking period, the mass of the receiver pan and collected test material was recorded and the percentage of test material with a particle size less than 100 μm calculated. As the percentage of the test item that passed through the 100 μm sieve was less than 10 %, further testing was not required.
Under the conditions of the study the percentage of test material having an inhalable particle size of less than 100 μm was determined to be 7.8 %. The test material has been considered to be essentially non-inhalable.
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