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EC number: 605-399-0 | CAS number: 165252-70-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
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- Boiling point
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- Endpoint summary
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- Ecotoxicological Summary
- Aquatic toxicity
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- Short-term toxicity to fish
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- Additional toxicological data

Biodegradation in soil
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in soil
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 17/05/2002 - 18/08/2003
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP, Guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: Commission Directive 95/36/EC of 14 July 1995 amending Council Directive 91/414/EEC: Annex II: 7.1.1.2 laboratory studies – aerobic degradation.
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: SETAC Europe: Procedures for assessing the environmental fate and ecotoxicity of pesticides, March 1995, Part 1 – Aerobic degradation
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: OECD Guidelines for testing chemicals: Aerobic – Anaerobic transformation in soil (Draft proposal, August 2000)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- laboratory
- Radiolabelling:
- yes
- Oxygen conditions:
- aerobic
- Soil classification:
- USDA (US Department of Agriculture)
- Soil no.:
- #1
- Soil type:
- silt loam
- % Clay:
- 10.3
- % Silt:
- 52.3
- % Sand:
- 37.4
- % Org. C:
- 1.8
- pH:
- 7.2
- CEC:
- 13.1 meq/100 g soil d.w.
- Soil No.:
- #1
- Duration:
- 120 d
- Soil No.:
- #1
- Initial conc.:
- 0.03 other: mg/100 g
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- radiochem. meas.
- test mat. analysis
- Soil No.:
- #1
- Temp.:
- 20 ± 2 ºC
- Humidity:
- 40% MWC (soil moisture)
- Microbial biomass:
- 30.3 g microbial C/kg dry sediment
- Soil No.:
- #1
- Temp.:
- 10 ± 2 ºC
- Humidity:
- 40% MWC (soil moisture)
- Microbial biomass:
- 30.3 g microbial C/kg dry sediment
- Details on experimental conditions:
- See Table 1
- Soil No.:
- #1
- % Recovery:
- 93.5
- St. dev.:
- 1.8
- Remarks on result:
- other: 20°C system
- Soil No.:
- #1
- % Recovery:
- 93.5
- St. dev.:
- 2.4
- Remarks on result:
- other: 10°C system
- Soil No.:
- #1
- DT50:
- 10.2 d
- Type:
- (pseudo-)first order (= half-life)
- Remarks on result:
- other: 20ºC system
- Soil No.:
- #1
- DT50:
- 21.1 d
- Type:
- (pseudo-)first order (= half-life)
- Remarks on result:
- other: 10ºC system
- Transformation products:
- yes
- No.:
- #1
- No.:
- #2
- Details on transformation products:
- Dinotefuran mainly degraded to MNG reaching a maximum amount of 15.6% and 16.0% AR in the 20°C and 10°C system, respectively. Additionally NG reached 5% AR on day 120 in the 10°C system and on day 62 in the 20°C system. Up to 9 minor degradation products were. Ultimate degradation to CO2 was significant reaching a maximum amount of 52.1% and 43.7% AR in the 20°C and 10°C system, respectively. Half lives for the degradation product MNG could be calculated.
- Evaporation of parent compound:
- not measured
- Volatile metabolites:
- not measured
- Residues:
- not measured
- Details on results:
- In the experiment, total recoveries of radioactivity (mass balances) were generally 93.5±1.8% applied radioactivity (AR) for the 20°C system and 93.5±2.4% for the 10°C system. Total extractable radioactivity declined rapidly from 94.1% on day 0 to 13.3% AR on day 120 in the 20°C system, and from 94.1% to 26.4% AR in the 10°C system. There were corresponding increases with time in non-extractable radioactivity with maxima of 25.7% AR in the 20°C system and 19.9% in the 10°C system. Organic matter fractionation indicated that the non-extractable radioactivity was mainly bound to the immobile humic acids and humic fraction. Volatile radioactivity, all associated with 14CO2, represented a maximum of 52.1% AR in the 20°C system and 43.7% AR in the 20°C system.
- Results with reference substance:
- No reference substance used
- Conclusions:
- Dinotefuran declined in aerobic soil systems with DT50 values of 10.2 and 21.1 days (20°C and 10°C system, respectively). One major degradation product was formed, MNG which accounted for up to 15.6% of the applied radioactivity at 20°C. NG was formed up to 5.4% of the applied radioactivity but only on one occasion. DT50 values of 87.7 days were calculated for MNG in 20°C system.
- Endpoint:
- biodegradation in soil
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 03/05/2002 - 11/02/2003
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP, Guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: Commission Directive 95/36/EC of 14 July 1995 amending Council Directive 91/414/EEC: Annex I: 7.1.1.2 rate of degradation; 7.1.1.1.2 anaerobic degradation study
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: SETAC Europe: Procedures for assessing the environmental fate and ecotoxicity of pesticides, March 1995, Part 1 –2 Anaerobic degradation
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: EPA 540/9-82-021; Section 162-2 Anaerobic soil metabolism studies
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- laboratory
- Radiolabelling:
- yes
- Oxygen conditions:
- anaerobic
- Soil classification:
- USDA (US Department of Agriculture)
- Soil no.:
- #1
- Soil type:
- silt loam
- % Clay:
- 10.3
- % Silt:
- 53.2
- % Sand:
- 37.4
- % Org. C:
- 1.78
- pH:
- 7.22
- CEC:
- 13.11 meq/100 g soil d.w.
- Details on soil characteristics:
- See Table 1
- Soil No.:
- #1
- Duration:
- 120 d
- Soil No.:
- #1
- Initial conc.:
- 0.031 other: mg/100 g
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- radiochem. meas.
- test mat. analysis
- Soil No.:
- #1
- Temp.:
- 20 ± 2ºC
- Microbial biomass:
- 33.0 g microbial C/kg dry sediment
- Soil No.:
- #1
- % Recovery:
- 96
- St. dev.:
- 2.5
- Remarks on result:
- other: total recoveries
- Soil No.:
- #1
- DT50:
- 22 d
- Type:
- (pseudo-)first order (= half-life)
- Remarks on result:
- other: water phase
- Soil No.:
- #1
- DT50:
- 77 d
- Type:
- (pseudo-)first order (= half-life)
- Remarks on result:
- other: total system
- Transformation products:
- yes
- No.:
- #1
- No.:
- #2
- Details on transformation products:
- Dinotefuran mainly degraded to DN (1- methyl-3-(tetrahydro-3-furylmethyl)guanidine) reaching a maximum amount of 33.1% AR; harsh extractions extracted additionally 8.7% of applied radioactivity as DN. Additionally UF (1-methyl-3-(tetrahydro-3-furylmethyl)urea) reached 7.7% AR on day 120. One more minor degradation product was detected chromatographically. Ultimate degradation to CO2 was low reaching a maximum amount of 4.2%.
Characterisation by HPLC and TLC co-chromatography with reference standard. - Evaporation of parent compound:
- not measured
- Volatile metabolites:
- not measured
- Residues:
- not measured
- Details on results:
- The degradation of dinotefuran in soil under anaerobic conditions was studied with 14C labelled test substance in two different labels. One soil system was set up at 20°C.
In the experiment, total recoveries of radioactivity (mass balances) were 96.0±2.5% of the applied radioactivity (AR). The radioactivity in water decreased from 94.6% on day 0 to 58.8% on day 7 and 25.4% on day 120. There was a corresponding increase of the radioactivity in soil reaching a maximum of 62.6% AR at the end of the test. The majority of it was extractable, amounting to 27.8% AR at day 3 and 53.5% at day 120. The maximum non-extractable radioactivity reached was 10.7% on day 59. Organic matter fractionation indicated that the non-extractable radioactivity was mainly bound to the immobile humic acids and humic fraction. Volatile radioactivity was mostly associated with 14CO2, representing a maximum of 4.2% AR. Only 0.1% AR were associated to organic volatiles. Dinotefuran mainly degraded to DN reaching a maximum amount of 33.1% AR; harsh extractions extracted additionally 8.7% of applied radioactivity as DN. Additionally UF reached 7.7% AR on day 120. One more minor degradation product was detected chromatographically. Ultimate degradation to CO2 was low reaching a maximum amount of 4.2%. - Results with reference substance:
- No reference substance used.
- Conclusions:
- Dinotefuran declined in anaerobic soil systems with DT50 values of 22 and 77 days in the water phase and total system, respectively. One major degradation product was formed, DN, i.e. l-methyl-3-(tetrahydro-3-furylmethyl)guanidine which accounted for up to 33.1% of the applied radioactivity. UF, i.e. l-methyl-3-(tetrahydro-3-furylmethyl)urea reached 7.7% of the applied radioactivity by the end of the test.
Referenceopen allclose all
Description of key information
Dinotefuran declined in aerobic soil systems with DT50 values of 10.2 and 21.1 days (20°C and 10°C system, respectively)
Dinotefuran declined in anaerobic soil systems with DT50 values of 22 and 77 days in the water phase and total system, respectively.
Key value for chemical safety assessment
- Half-life in soil:
- 19.2 d
- at the temperature of:
- 12 °C
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