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Environmental fate & pathways

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The hydrolysis data requirement for 2-[[2-(dimethylamino)ethyl]methylamino]ethanol (CAS 2212-32-0) has been waived on the basis that given the intrinsic nature of alkylamines, the activation energy requirements necessary for hydrolysis to occur will not be met under natural environmental conditions. As such, 2-[[2-(dimethylamino)ethyl]methylamino]ethanol can be concluded to be hydrolytically stable and further studies would be unnecessary.

A reliable, GLP compliant experimental aerobic ready biodegradability study was conducted according to EG-guideline 92/69/EWG (equivalent to the OECD 301A Guideline (ready biodegradability: DOC Die Away Test) and ISO 7827 method). There were no deviations from the test guideline and the validity criteria for testing of ready biodegradability according to OECD criteria were fulfilled. The reference substance aniline showed 95% degradation (DOC removal) after 5 days, however only 1% degradation (DOC removal) of the test substance, 2-[[2-(dimethylamino)ethyl]methylamino]ethanol (CAS 2212-32-0), was shown after 28 days, and is therefore concluded to be not readily biodegradable.  

The adsorption/desorption data requirement for 2-[[2-(dimethylamino)ethyl]methylamino]ethanol (CAS 2212-32-0) has been waived on the basis that the substance has shown to have a low octanol-water partition coefficient value of -0.584, thereby indicating low adsorption potential.

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