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Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
30/03/2016
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Justification for type of information:
GLP study performed using an accepted method
Qualifier:
according to
Guideline:
EU Method A.4 (Vapour Pressure)
Deviations:
no
Qualifier:
according to
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
effusion method: vapour pressure balance
Specific details on test material used for the study:
Appearance/Physical State: Yellow liquid
Batch: 1721964
Purity: 99.0%
Expiry Date: 08 April 2016
Storage Conditions: Room temperature in the dark
Key result
Temp.:
25 °C
Vapour pressure:
ca. 57.5 Pa
Key result
Transition / decomposition:
no
Remarks:
The test item did not change in appearance under the conditions used in the test

Recorded temperatures, mass differences and the resulting calculated values of vapour pressure are as follows: 

Temp. (ºC)

Temp. (K)

Reciprocal temp. (K-1)

Mass difference (μg)

Mass difference (kg)

Vapour pressure (Pa)

Log10 Vp

-25

248.15

0.004029821

176.81

1.768E-07

0.245457578

-0.610023555

-24

249.15

0.004013646

203.43

2.034E-07

0.282412958

-0.549115380

-23

250.15

0.003997601

221.94

2.219E-07

0.308109581

-0.511294797

-22

251.15

0.003981684

258.81

2.588E-07

0.359294587

-0.444549326

-21

252.15

0.003965893

299.61

2.996E-07

0.415935440

-0.380974074

-20

253.15

0.003950227

340.28

3.403E-07

0.472395819

-0.325693955

-19

254.15

0.003934684

433.02

4.330E-07

0.601142699

-0.221022423

-18

255.15

0.003919263

427.71

4.277E-07

0.593771059

-0.226380974

-17

256.15

0.003903963

467.14

4.671E-07

0.648510001

-0.188083322

-16

257.15

0.003888781

530.55

5.306E-07

0.736539326

-0.132804060

-15

258.15

0.003873717

588.28

5.883E-07

0.816683356

-0.087946295

Data are only provided for Run 1 

A plot of Log10 (vapour pressure (Pa)) versus reciprocal temperature (1/T(K)) for Run 1 gives the following statistical data using an unweight least squares treatment.

Slope: -3.40 x 103

Standard error in slope: 135

Intercept: 13.1

Standard error in intercept: 0.533

The results obtained indicate the following vapour pressure relationship:

Log10 (Vp (Pa)) = -3.40 x 103 / temp(K) + 13.1

The above yields a vapour pressure (Pa) at 298.15 K with a common logarithm of 1.70.

The values of vapour pressure at 25 °C extrapolated from of the six determinations are summarized below: 

Run

Log10 Vp at 25 ºC

Vapour pressure (Pa)

1

1.70 Pa

50.1

2

1.76 Pa

57.5

3

1.81 Pa

64.6

4

1.78 Pa

60.3

5

1.72 Pa

52.5

6

1.79 Pa

61.7

Mean

1.76 Pa

57.5

Conclusions:
The vapor pressure of the test item has been determined to be 58 Pa at 25 ºC.
Executive summary:

The vapour pressure of 2-[[2-(Dimethylamino)ethyl]methylamino]ethanol (CAS: 2212-32-0) was determined to be 58 Pa at 25 °C, using the vapour pressure balance method, designed to be compatible with Method A4 Vapour Pressure of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 104 of the OECD Guidelines for Testing of Chemicals, 23 March 2006.

Description of key information

The vapour pressure of 2-[[2-(Dimethylamino)ethyl]methylamino]ethanol (CAS: 2212-32-0) was determined to be 58 Pa at 25 °C, using the vapour pressure balance method, designed to be compatible with Method A4 Vapour Pressure of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 104 of the OECD Guidelines for Testing of Chemicals, 23 March 2006.

Key value for chemical safety assessment

Vapour pressure:
58 Pa
at the temperature of:
25 °C

Additional information