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EC number: 207-353-1
CAS number: 464-45-9
Summary of findings in bone marrow erythrocytes:
Erythrocytes with micronuclei
Mut. I = Mutagenic index
- = No difference from control (P>0.05
I = within the normal range
* = Significantly different from control (P<0.05)
A = Outside the normal range
An in-vivo micronucleus test was performed with isobornyl acetate
according to OECD 474. Five mice per sex and per group (70 in total)
were exposed to a single dose of test item at 2000 mg/kg bw, based on
preliminary results. Cyclophosphamide was used as a positive control (5
mice per sex). Animals were killed 24, 48 and 72 hours after
administration of the test compound. For each animal, bone marrow smears
were flushed from both femora and the slides were prepared for
erythrocyte micronuclei observation. The number of polychromatic and
normochromatic erythrocytes containing micronuclei was not increased.
The ratio of polychromatic/normochromatic erythrocytes in both male and
female animals remained unaffected by the treatment and was
statistically not different from the control values, indicating no
mutagenicity. Based on these results, isobornyl acetate was determined
to be not mutagenic in the mammalian erythrocyte micronucleus test.
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