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EC number: 222-824-1 | CAS number: 3623-51-6
To correct the interspecies difference between rat and human the no observed effect level has to be corrected as follows:
Corrected starting point for the inhalative route for workers:
= NOAEL(oral) * (1/0.38 m³/kg bw/day) * (ABSoral-rat/ABSinh-human) * 6.7 m³ (8h) /10 m³ (8h)
= 375 mg/kg bw/day * (1/0.38 m³/kg bw/day) * (1/1) * 0.67 m³ = 661 mg/m³
Based on the toxicokinetic data, it can be assumed that the systemic bioavailability will be high both after oral and inhalation exposure; oral absorption rate in rats and inhalation absorption rate in humans is assumed to be the same.
(ABSoral-rat = oral absorption in rats, ABSinh-human = inhalation absorption rate in humans)
Thus, the corrected starting point for workers was 661.2 mg/m³ for inhalation.
Dermal NOAEL = oral NOAEL*ABS(oral)/ABS(dermal) = 375 mg/kg bw/day *(1/1) = 375 mg/kg bw/day. It is assumed that oral and dermal absorption rates are equal.
Dermal NOAEC=oral NOAEL*ABS(oral)/ABS(dermal) = 375 mg/kg bw/day *(1/1) = 375 mg/kg bw/day. It is assumed that oral and dermal absorption rates are equal.
no route to route extrapolation necessary
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