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EC number: 214-494-2 | CAS number: 1135-66-6
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- experimental data of read across substances
- Justification for type of information:
- Data for the target chemical is summarized based on the structurally similar read across chemicals
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- WoE report is based on two hydrolysis studies as-
1., 2. and 3. - GLP compliance:
- not specified
- Specific details on test material used for the study:
- - Name of test material (IUPAC name): (2S)-1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-2H-2,4a-methanonaphthalene
- Common name: Isolongifolene
- Moleuclar formula: C15H24
- Molecular weight: 204.3546 g/mol
- Substance type: Organic
- Smiles: CC1(C)CCC=C2C(C)(C)[C@H]3CC[C@@]12C3
- Inchi: 1S/C15H24/c1-13(2)8-5-6-12-14(3,4)11-7-9-15(12,13)10-11/h6,11H,5,7-10H2,1-4H3/t11-,15-/m0/s1
- Physical state: liquid - Oxygen conditions:
- other: 1. and 2. No data available, 3. aerobic
- Inoculum or test system:
- other: 1. and 2. No data available, 3. activated sludge (adaptation not specified)
- Details on inoculum:
- 1. and 2. No data available
3. - Concentration of sludge: 30 mg/l - Duration of test (contact time):
- 28 d
- Based on:
- other: 1. Details not known
- Initial conc.:
- 100 mg/L
- Based on:
- test mat.
- Remarks:
- 2. and 3.
- Parameter followed for biodegradation estimation:
- O2 consumption
- Remarks:
- 1.
- Parameter followed for biodegradation estimation:
- test mat. analysis
- Remarks:
- 2. (%degradation)
- Parameter followed for biodegradation estimation:
- other: 3. BOD and GC
- Details on study design:
- 1. and 2. No data available
3. Standard type - Parameter:
- % degradation (O2 consumption)
- Value:
- 74
- Sampling time:
- 28 d
- Remarks on result:
- other: 1. Other details not known
- Parameter:
- % degradation (test mat. analysis)
- Value:
- 59
- Sampling time:
- 10 d
- Remarks on result:
- other: 2. Other details not known
- Parameter:
- % degradation (test mat. analysis)
- Value:
- 67
- Sampling time:
- 14 d
- Remarks on result:
- other: 2. Other details not known
- Parameter:
- % degradation (test mat. analysis)
- Value:
- 75
- Sampling time:
- 20 d
- Remarks on result:
- other: 2. Other details not known
- Parameter:
- % degradation (test mat. analysis)
- Value:
- 83
- Sampling time:
- 28 d
- Remarks on result:
- other: 2. Other details not known
- Parameter:
- other: BOD
- Value:
- 94
- Sampling time:
- 28 d
- Remarks on result:
- other: 3. Other details not known
- Parameter:
- other: GC
- Value:
- 100
- Sampling time:
- 28 d
- Remarks on result:
- other: 3. Other details not known
- Details on results:
- 1. Test chemical undergoes 74% degradation by O2 consumption parameter in 28 days.
2. Test chemical undergoes 59, 67, 75 and 83% degradation by Test material analysis parameter in 10, 14, 20 and 28 days, respectively.
3. Test chemical undergoes 94% and 100% degradation by BOD and GC parameter in 28 days. - Validity criteria fulfilled:
- not specified
- Interpretation of results:
- readily biodegradable
- Conclusions:
- On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the percentage degradation of the test chemical can be expected to be 74, 83, 94 and 100% by O2 consumption, test material analysis, BOD and GC parameter in total 28 days, respectively. Thus, based on this, it can be concluded that the test chemical is readily biodegradable in water.
- Executive summary:
Data available for the test chemical has been reviewed to determine the percentage biodegradation. The studies are as mentioned below:
The percentage degradation of test chemical was determined to be 74% by O2 consumption parameter in 28 days. Thus, based on percentage degradation, test chemical is considered to be readily biodegradable in water.
In an another study, biodegradation experiment was conducted for 28 days for evaluating the percentage biodegradability of test chemical. The study was performed according to Council Directive 92/69/EEC Method C.4-D guidelines. Initial test substance conc. used in the study was 100 mg/l. The percentage degradation of test chemical was determined to be 59, 67, 75 and 83% by Test material analysis parameter in 10, 14, 20 and 28 days, respectively. Thus, based on percentage degradation,test chemical is considered to be readily biodegradable in nature.
Another biodegradation study was conducted for 28 days for evaluating the percentage biodegradability of test chemical. The study was performed according to OECD Guideline 301 C (Ready Biodegradability: Modified MITI Test (I) under aerobic conditions. Activated sludge was used as a test inoculums for the study. Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l, respectively. The percentage degradation of test chemical was determined to be 94% and 100% by BOD and GC parameter in 28 days. Thus, based on percentage degradation, test chemical is considered to be readily biodegradable in nature.
On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the percentage degradation of the test chemical can be expected to be 74, 83, 94 and 100% by O2 consumption, test material analysis, BOD and GC parameter in total 28 days, respectively. Thus, based on this, it can be concluded that the test chemical is readily biodegradable in water.
Reference
Description of key information
On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the percentage degradation of the test chemical can be expected to be 74, 83, 94 and 100% by O2 consumption, test material analysis, BOD and GC parameter in total 28 days, respectively. Thus, based on this, it can be concluded that the test chemical is readily biodegradable in water.
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
Additional information
Data available for the test chemical has been reviewed to determine the percentage biodegradation. The studies are as mentioned below:
The percentage degradation of test chemical was determined to be 74% by O2 consumption parameter in 28 days. Thus, based on percentage degradation, test chemical is considered to be readily biodegradable in water.
In an another study, biodegradation experiment was conducted for 28 days for evaluating the percentage biodegradability of test chemical. The study was performed according to Council Directive 92/69/EEC Method C.4-D guidelines. Initial test substance conc. used in the study was 100 mg/l. The percentage degradation of test chemical was determined to be 59, 67, 75 and 83% by Test material analysis parameter in 10, 14, 20 and 28 days, respectively. Thus, based on percentage degradation,test chemical is considered to be readily biodegradable in nature.
Another biodegradation study was conducted for 28 days for evaluating the percentage biodegradability of test chemical. The study was performed according to OECD Guideline 301 C (Ready Biodegradability: Modified MITI Test (I) under aerobic conditions. Activated sludge was used as a test inoculums for the study. Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l, respectively. The percentage degradation of test chemical was determined to be 94% and 100% by BOD and GC parameter in 28 days. Thus, based on percentage degradation, test chemical is considered to be readily biodegradable in nature.
On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the percentage degradation of the test chemical can be expected to be 74, 83, 94 and 100% by O2 consumption, test material analysis, BOD and GC parameter in total 28 days, respectively. Thus, based on this, it can be concluded that the test chemical is readily biodegradable in water.
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