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EC number: 214-494-2 | CAS number: 1135-66-6
Classification of (2S)-1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-2H-2,4a-methanonaphthalene (CAS no. 1135-66-6) for effects in the environment:
The test chemical (2S)-1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-2H-2,4a-methanonaphthalene (CAS no. 1135-66-6) is used in air care products, biocides (e.g. disinfectants, pest control products), perfumes and fragrances, polishes and waxes and cosmetics and personal care products. The test chemical herein critically and independently evaluated for the PBT.
The aim was to assess whether the PBT criterion within Annex XIII was fulfilled for(2S)-1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-2H-2,4a-methanonaphthalene. The PBT criterion was herein assessed based on experimental data in conjunction with standardized environmental fate models. Here follows a description of the PBT assessment.
1. Persistence assessment
The tested substance doesn’t meet the P criterion within Annex XIII based on the assessment that here follows:
By gathering all the Experimental data from various sources, for similar read across chemical. The surrogate chemicals have the percentage degradation of 74, 83, 94 and 100% for the period of 28 days. Based on the weight of evidence approach for assessment of test chemical, CAS 1135-66-6 can be considered as readily biodegradable chemical.
In conclusion, the chemical was estimated to be non-persistent in water, because of it biodegradable nature.
2. Bioaccumulation assessment
The tested substance does meet the B criterion within Annex XIII based on the assessment that here follows:
I. The partition Coefficient n-octanol/water of test chemical is 5.7. Based on the logKow values, it is expected that the test chemical will have potential to get bioaccumulate in the aquatic organisms.
J. The prediction approach for the test chemical, on bioaccumulation study reveals that the test chemical has potential to get accumulate in the visceral organs of the aquatic species. The BCF value of test compound 3019, which is higher than the standard value 2000.
3. Toxicity assessment
The tested substance doest meet the T criterion within Annex XIII based on the assessment that here follows:
The substance didn’t fulfil the criteria for the mammalian toxicity, neither CMR nor STOT RE as per ANNEX XIII of PBT classification.
3.2. Freshwater organisms
Test chemical was investigated for any adverse effects caused to the aquatic species (Fish, Daphnia and algae). The prediction and read across chemical approach has been used for the assessment of the toxicity. The toxic values were ranging between 0.04 to 0.72 mg/L. Based on the toxic values the test chemical can be hazardous in nature and classified into aquatic acute category 1.
By considering the toxic values it can be assumed that the NOEC values for the long-term exposure would be lower than the threshold value 0.01 mg/L. Thus, it can be classified as toxic chemical as per Annex XIII for PBT classification.
Overall conclusion about Persistence, Bioaccumulation and Toxicity (PBT).
Based on critical, independent and collective evaluation of information summarized herein, the tested compound didn’t meet the P criterion within Annex XIII. Hence, the tested compound has not been classified as a PBT compound within Annex XIII.
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