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Physical & Chemical properties

Solubility in organic solvents / fat solubility

Administrative data

Endpoint:
solubility in organic solvents / fat solubility
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
no data
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Insufficient documentation for an assessment of reliability.
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
study report
Title:
Unnamed

Materials and methods

Principles of method if other than guideline:
no data
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
616-145-3
Cas Number:
74852-61-2
Molecular formula:
C17H19N3O3
IUPAC Name:
616-145-3
Test material form:
solid: particulate/powder
Details on test material:
- Name of test material (as cited in study reports): JNJ-1806792-AAA (T001325)
- Physical state: solid (powder)
- Appearance: brown powder

Results and discussion

Solubility in organic solvents / fat solubilityopen allclose all
Medium:
methanol
Solubility:
0.02 other: g/100 mL solution
Medium:
ethanol
Solubility:
0.017 other: g/100 mL solution
Medium:
isopropanol
Solubility:
0.008 other: g/100 mL solution
Medium:
other: dichloromethane
Solubility:
2.73 other: g/100 mL solution
Medium:
other: 2-propanone
Solubility:
0.39 other: g/100 mL solution
Medium:
other: 1,1'-oxybisethane
Solubility:
0.029 other: g/100 mL solution
Medium:
other: methylbenzene
Solubility:
0.22 other: g/100 mL solution
Medium:
other: 4-methyl-2-pentanone
Solubility:
0.26 other: g/100 mL solution
Medium:
other: 2-butanone
Solubility:
0.49 other: g/100 mL solution
Medium:
other: 2,2'-oxybispropane
Solubility:
0.008 other: g/100 mL solution
Details on results:
no data

Any other information on results incl. tables

Table 1 Solubility of the T001325 at 20 deg C (Condition 10)

 Solvent  Solubility in g/100 mL solution
dichloromethane  3.6
acetic acid  0.57
 N,N-dimethylacetamide  1.9

Applicant's summary and conclusion