Disodium 4,4'-bis[[1-[[(2,4-dimethylphenyl)amino]carbonyl]-2-oxopropyl]azo][1,1'-biphenyl]-2,2'-disulphonate

Water solubility

Administrative data

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

from 25 April 2016 to 15 May 2017

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Cross-reference

Reason / purpose for cross-reference:

reference to other study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2017

Report date:

2017

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Version / remarks:

2014

Deviations:

no

Test guideline 2

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Version / remarks:

1995

Deviations:

no

Test guideline 3

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7840 (Water Solubility)

Version / remarks:

1998

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

flask method

Test material

Reference

Name:

Unnamed

Type:

Constituent

Test material form:

solid: particulate/powder

Details on test material:

- Appearance: yellow/brown powder
- Storage conditions: in refrigerator (2-8°C)

Results and discussion

Water solubility

Key result

Water solubility:

27.5 g/L

Incubation duration:

>= 48 - <= 72 h

Temp.:

20.1 °C

pH:

5.8

Details on results:

Concentration analysed after 24, 48 and 72 hours of stirring was 33.7 g/L, 28.1 g/L and 26.9 g/L, resp.

The 24-hour measurement was significantly higher than the 48- and 72- hour measurements (maximum difference > 15%). Therefore, the water solubility of the test item was given as the mean value of the 48- and 72-hour measurements (maximum difference of 4.4%).

Applicant's summary and conclusion

Conclusions:

The water solubility of the substance at 20°C was determined to be 27.5 g/L.

Executive summary:

The water solubility of the substance was determined using the flask method in a GLP study according to EC A.6, OECD 105 and OPPTS 830.7840. Quantification was performed by UPLC-MS-MS. The pH of the aqueous samples at all sampling times was 5.8. From the measurements obtained after 48 and 72 hours of stirring, the water solubility at 20°C was determined to be 27.5 g/L.