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EC number: 250-426-8 | CAS number: 31001-77-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- Summary report only available.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- not specified
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 3-trimethoxysilylpropane-1-thiol
- EC Number:
- 224-588-5
- EC Name:
- 3-trimethoxysilylpropane-1-thiol
- Cas Number:
- 4420-74-0
- IUPAC Name:
- 3-(trimethoxysilyl)propane-1-thiol
- Details on test material:
- - Name of test material (as cited in study report): Organofunctional Silane Y-9616 (gamma-mercaptopropyltrimethoxysilane)
- Substance type: Organosilane
- Physical state: Liquid
- Stability under test conditions:
- Storage condition of test material: No data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: No data
- Age at study initiation: No data
- Weight at study initiation: 200-300 g
- Fasting period before study: yes, overnight
- Housing: No data
- Diet (e.g. ad libitum): Ad libitum
- Water (e.g. ad libitum): Ad libitum
- Acclimation period: No data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): No data
- Humidity (%): No data
- Air changes (per hr): No data
- Photoperiod (hrs dark / hrs light): No data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: Dose was varied by altering the volume.
- Doses:
- Male rats: 2.0, 1.0, 0.71 and 0.5 ml/kg bw.
Female rats: 1.0, 0.71, 0.5 and 0.25 ml/kg bw - No. of animals per sex per dose:
- Five (two in highest dose males)
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Weighing at day 0 (prior to dosing), day 7 and day 14
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, gross pathology - Statistics:
- LD50s calculated using the moving averages method.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- ca. 0.88 mL/kg bw
- Remarks on result:
- other: 0.88 ml/kg x 1.015 (SG) = 893 mg/kg bw
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- ca. 0.73 mL/kg bw
- Remarks on result:
- other: 0.73 ml/kg x 1.015 (SG) = 741 mg/kg bw
- Mortality:
- For males, both of the highest dose and 4/5 of the 1.0 mg/kg bw groups died within the first day after dosing (one died on Day 2). For females all of the highest dose, and 2/5 of the 0.71 mg/kg bw group died within the first day after dosing.
- Clinical signs:
- other: Sluggishness, unsteady gait, lacrimation, yellow or red wetness or stains on the periurogenital fur, blood in the urine, a red crust around the nose and eyes, and prostration (in two animals).
- Gross pathology:
- Animals that died revealed discoloured and/or mottled lungs (pink, red or salmon-coloured), discoloured stomachs and intestines (white to yellow, red or grey), gas and liquid filled stomachs and intestines, dark red or mottled tan livers, dark red to brown kidneys, liquid-filled abdominal cavities, one bladder filled with red liquid and blood in urine. Survivors had mottled pink to red lungs. One male had small mottled testes with cream-coloured foci and red submandibular lymph nodes.
- Other findings:
- - Histopathology: The kidneys and urinary bladders from two male and two female rats from all dosages were examined histologically. There was tubular proteinosis in the kidneys of male rats from each dose. No significant lesions were found in the male rat bladders or in the female kidneys or bladders.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- In a summary of an acute oral toxicity study (reliability score 2; not to GLP) the oral LD50 for Organofunctional Silane Y-9616 (gamma-mercaptopropyltrimethoxysilane), in Sprague-Dawley rats, was 0.88 ml/kg bw for males and 0.73 ml/kg bw for females.
- Executive summary:
Organofunctional Silane Y-9616 (gamma-mercaptopropyltrimethoxysilane) was given to Sprague-Dawley rats by oral gavage at doses of 2.0, 1.0, 0.71 and 0.5 ml/kg bw for male rats and 1.0, 0.71, 0.5 and 0.25 ml/kg bw for female rats. Animals were then observed for 14 days, Body weights were determined immediately prior to dosing and on Days 7 and 14. At the end of the observation period all animals surviving were killed and a gross pathological examination performed on each animal. Animals that died were similarly examined. Kidneys and urinary bladder from two males and two females from each exposure group were subjected to a detailed histopathology examination. For males, both of the highest dose, and 4/5 of the 1.0 ml/kg bw groups died within the first day after dosing (one died on Day 2). For females all of the highest dose, and 2/5 of the 0.71 ml/kg bw group died within the first day after dosing. Clinical signs were sluggishness, unsteady gait, lacrimation, yellow or red wetness or stains on the periurogenital fur, blood in the urine, a red crust around the nose and eyes, and prostration (in two animals). Animals that died revealed discoloured and/or mottled lungs (pink, red or salmon-coloured), discoloured stomachs and intestines (white to yellow, red or grey), gas and liquid filled stomachs and intestines, dark red or mottled tan livers, dark red to brown kidneys, liquid-filled abdominal cavities, one bladder filled with red liquid and blood in urine. Survivors had mottled pink to red lungs. One male had small mottled testes with cream-coloured foci and red submandibular lymph nodes. Detailed histopathological examination of the kidneys and urinary bladders revealed tubular proteinosis in the kidneys of male rats from each dose. No significant lesions were found in the male rat bladders or in the female kidneys or bladders. There were no effects on body weights. The LD50s for males and females were 0.88 and 0.73 ml/kg bw, respectively.
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