Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 227-057-6 | CAS number: 5625-37-6
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- ANALOGUE APPROACH JUSTIFICATION
Please refer to the attached read across justification in section 13. - Reason / purpose for cross-reference:
- read-across source
- Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- -2
- Sampling time:
- 28 d
Reference
Description of key information
In a study according to OECD TG 301 D under GLP, the source substance was found to be not readily biodegradable. Therefore, the target substance is considered to be not readily biodegradable (reference 5.2.1-1).
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
- Type of water:
- freshwater
Additional information
No experimental data on biodegradation with test item was available. Read-across to a structural analogous substance was done instead.
The read-across source substance was investigated for its ready biodegradability in a Closed Bottle Test according to OECD TG 301 D under GLP conditions over a period of 28 days. The biodegradation was measured by the determination of the oxygen uptake of the microorganisms during exposure. As a reference item Aniline was tested simultaneously under the same conditions as the test item, and functioned as a procedure control. Under the test conditions the percentage biodegradation of the test item, based on ThODNH4, reached in the mean -2 % after 28 days of incubation. If the calculation of biodegradation is based on ThODNO3, percentage biodegradation reached in the mean -1 % after 28 days of incubation. The reference item Aniline was sufficiently degraded to 84 % after 14 days, and to 93 % after 28 days of incubation, thus confirming the suitability of the used activated sludge inoculum. In the toxicity control containing both, the test item and the reference item Aniline, the mean of 36 % biodegradation was noted within 14 days and 46 % biodegradation after 28 days of incubation. Thus, the test item can be assumed to be not inhibitory on the activated sludge microorganisms. The degradation rate of the test material did not reach 60 % within the 10day window and after 28 days of incubation. Thus the test item is not readily biodegradable.
Based on the data from the read-across source substance, the target substance is determined to be not readily biodegradable.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
