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EC number: 268-516-0 | CAS number: 68110-27-0
The test substance, Reactive Yellow 85, was tested for the evaluation the potential ocular corrosivity or severe irritancy as measured by its ability to induce opacity and increased permeability in an isolated bovine cornea.
The test was performed according to the OECD Test Guideline No. 437, Bovine Corneal Opacity and Permeability Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage, Adopted 26th July 2013.
The test was performed using nine isolated bovine corneas. The testing was performed on three groups of corneas: test substance treatment group, positive control group and negative control group. Three corneas per group were used.
Open-chamber method was used, because the test substance was viscous. The opacity and permeability of each cornea were measured. The In Vitro Irritancy Score (IVIS) was calculated from the values of opacity and permeability.
The In Vitro Irritancy Score (IVIS) for Reactive Yellow 85 was 17.65 but this result could be affected by higher opacity values (corneas were coloured by the test substance: mild yellow colour).
On the basis of IVIS score the classification according to the criteria of the UN GHS resulted in category “No prediction can be made”. But because of the colouring of corneas this result is ambiguous.
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