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Toxicological information

Skin sensitisation

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Administrative data

Endpoint:
skin sensitisation: in vivo (non-LLNA)
Type of information:
calculation (if not (Q)SAR)
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
accepted calculation method
Justification for type of information:
Data is from Danish QSAR

Data source

Reference
Reference Type:
other: Authoritative data base
Title:
Danish QSAR study for CAS No.: 1195-79-5
Author:
Danish (Q)SAR Database
Year:
2018
Bibliographic source:
Database developed by National Food Institute, Technical University of Denmark, with support from the Danish Environmental Protection Agency, the Nordic Council of Ministers and the European Chemicals Agency.

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: estimated data
Principles of method if other than guideline:
Prediction is done by using Danish QSAR
GLP compliance:
not specified
Type of study:
other: Allergic Contact Dermatitis in Guinea Pig and Human
Justification for non-LLNA method:
Not specified.

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid
Details on test material:
- Name of test material : 3, 3-Dimethyl-8, 9-dinorbornan-2-one
- Common name : 1,3,3-trimethylbicyclo[2.2.1]heptan-2-one
- Molecular formula : C10H16O
- Molecular weight : 152.2354 g/mol
- Smiles notation : C[C@@]12CC[C@@H](C1)C(C)(C)C2=O
- InChl : 1S/C10H16O/c1-9(2)7-4-5-10(3,6-7)8(9)11/h7H,4-6H2,1-3H3/t7-,10+/m0/s1
- Substance type: Organic
- Physical state: Liquid
Specific details on test material used for the study:
- Name of test material: 3,3-Dimethyl-8,9-dinorbornan-2-one
- Common name: 1,3,3-trimethylbicyclo[2.2.1]heptan-2-one / Fenchone
- Molecular formula: C10H16O
- Molecular weight: 152.2354 g/mol
- Smiles notation: C[C@@]12CC[C@@H](C1)C(C)(C)C2=O
- InChl: 1S/C10H16O/c1-9(2)7-4-5-10(3,6-7)8(9)11/h7H,4-6H2,1-3H3/t7-,10+/m0/s1
- Substance type: Organic
- Physical state: Liquid

In vivo test system

Test animals

Species:
other: Guinea Pig and Human
Strain:
not specified
Sex:
not specified

Study design: in vivo (non-LLNA)

Induction
Route:
other: No data available.
Challenge
Route:
other: No data available.
No. of animals per dose:
No data available.
Details on study design:
No data available.
Challenge controls:
No data available.
Positive control substance(s):
not specified

Study design: in vivo (LLNA)

Statistics:
No data available.

Results and discussion

In vivo (non-LLNA)

Results
Reading:
1st reading
Group:
test group
No. with + reactions:
0
Clinical observations:
No skin sensitization effect were observed.
Remarks on result:
no indication of skin sensitisation

Any other information on results incl. tables

Domain applicability: In domain

Applicant's summary and conclusion

Interpretation of results:
other: Not sensitizing
Conclusions:
According to Danish QSAR database , the skin sensitization effects were estimated by using four different models i.e, Battery, Leadscope, SciQSAR and CASE Ultra for 3,3-Dimethyl-8,9-dinorbornan-2-one (CAS No: 1195-79-5) . Based on estimation, no skin sensitization reactions were observed in guinea Pig and Human. Therefore, 3,3-Dimethyl-8,9-dinorbornan-2-one (CAS No: 1195-79-5) was considered to be not sensitizing.
Executive summary:

According to Danish QSAR database , the skin sensitization effects were estimated by using four different models i.e, Battery, Leadscope, SciQSAR and CASE Ultra for3,3-Dimethyl-8,9-dinorbornan-2-one (CAS No: 1195-79-5) . Based on estimation, no skin sensitization reactions were observed in guinea Pig and Human. Therefore, 3,3-Dimethyl-8,9-dinorbornan-2-one (CAS No: 1195-79-5) was considered to be not sensitizing.