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EC number: 235-397-1 | CAS number: 12217-38-8
Determination of the primary non-irritant concentration
The skin surface of the animals was discolored light yellow but no signs of irritation occurred after administration of the different test concentrations.
Based on these resuits, 100 % of test substance was selected for the sensitization treatments.
Body weight gains and clinical signs
The body weight gains of the animais were not impaired. The treated animals showed no clinical signs of intoxication throughout the study.
Irritations during the sensitization phase
The skin surface of the animals was discolored light yellow in the treatment group during the sensitization phase. The animais of the control group showed no signs of irritation.
Dermal challenge treatment
The skin surface of the animals was discolored tight yellow in the control and the treatment group 24 and 48 hours after removal of the occlusive bandage.
Testing for the sensitizing properties of the tested substance was performed in female guinea pigs according to the method of BUEHLER (OECD guideline 406).
Dermal induction was performed using 100 % of the test substance moistened with 0.8 ml of deionized water. The control group was exposed to deionized water only. Challenge treatment was carried out with 100 % of test substance moistened with 0.8 ml of deionized water.
The validity of the test system is confirmed by the periodically conducted positive contral test using alpha-hexyl cinnamic aldehyde for the BUEHLER test.
Under the conditions of the present study, none of twenty animais of the treatment group showed a positive skin response after the challenge procedure. Thus, the percentage of animals reacting positive is below the threshold of 15 %.
Based on the results of this study the test substance showed no evidence for sensitizing properties.
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