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EC number: 212-214-3 | CAS number: 769-78-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 16 Jul - 14 Aug 2008
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- adopted 24 Apr 2002
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Version / remarks:
- Commission Directive No. 2004/73/EC
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- THE DEPARTMENT OF HEALTH OF THE GOVERNMENT OF THE UNITED KINGDOM
Test material
- Reference substance name:
- Vinyl benzoate
- EC Number:
- 212-214-3
- EC Name:
- Vinyl benzoate
- Cas Number:
- 769-78-8
- Molecular formula:
- C9H8O2
- IUPAC Name:
- vinyl benzoate
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan UK Limited, Bicester, Oxon, UK
- Age at study initiation: 12 - 20 weeks
- Weight at study initiation: 2.0 - 3.5 kg
- Housing: individually in suspended cages
- Diet: 2030 Teklad Global Rabbit diet (Harlan Teklad, Blackthorn, Bicester, Oxon, UK), ad libitum
- Water: drinking water, ad libitum
- Acclimation period: at least five days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 17 - 23
- Humidity (%): 30 - 70
- Air changes (per hr): at least 15
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount applied: 0.5 mL - Duration of treatment / exposure:
- Initial test: 3 min, 1 and 4 h
Confirmatory test: 4 h - Observation period:
- 14 days
- Number of animals:
- 3 males
- Details on study design:
- TEST SITE
- Area of exposure: 2.5 x 2.5 cm on the dorsal/flank area of the trunk
- Type of wrap if used: Each gauze patch was secured in position with a strip of surgical adhesive tape and the trunk of the rabbit was wrapped in an elasticated corset.
REMOVAL OF TEST SUBSTANCE
- Washing: Any residual test material was removed by gentle swabbing with cotton wool soaked in distilled water.
- Time after start of exposure: Initial test: 3 min, 1 and 4 h; Confirmatory test: 4 h
OBSERVATION TIME POINTS
1, 24, 48 and 72 h and Day 7 and 14
SCORING SYSTEM
- Method of calculation: Draize scoring system
OTHER OBSERVATIONS
Body weights were measured before dosing (Day 0) and on Day 14.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Remarks:
- 4 h exposure
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- erythema score
- Remarks:
- 4 h exposure
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- erythema score
- Remarks:
- 4 h exposure
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- erythema score
- Remarks:
- 4 h exposure
- Basis:
- mean
- Remarks:
- of 3 animals
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- edema score
- Remarks:
- 4 h exposure
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 14 days
- Remarks:
- Crust formation prevents evaluation of edema on Day 7 and slight edema was observed on Day 14.
- Irritation parameter:
- edema score
- Remarks:
- 4 h exposure
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 1.33
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- edema score
- Remarks:
- 4 h exposure
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- edema score
- Remarks:
- 4 h exposure
- Basis:
- mean
- Remarks:
- of 3 animals
- Time point:
- 24/48/72 h
- Score:
- 1.44
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Irritant / corrosive response data:
- 3 min exposure period:
Very slight erythema was noted at the treated skin site at the 24-hour observation. Well-defined erythema and very slight oedema were noted at the treated skin site at the 48 and 72-hour observations. The reaction extended approximately 3 cm beyond the treatment site at the 24 and 48-hour observations. Crust formation was noted at the treated skin site at the 7-day observation and slight desquamation was noted at the 14-day observation.
1 h exposure period:
Very slight erythema was noted at the treated skin site one hour after patch removal. Well-defined erythema and very slight to slight oedema were noted at the treated skin site at the 24, 48 and 72-hour observations. The reaction extended approximately 3 cm beyond the treatment site at the 24, 48 and 72-hour observations. Crust formation, which prevented accurate evaluation of erythema and oedema, was noted at the treated skin site at the 7-day observation. Slight desquamation was noted at the treated skin site at the 14-day observation.
4 h exposure period:
Well-defined erythema and very slight oedema were noted at two treated skin sites and very slight erythema was noted at one treated skin site one hour after patch removal. Well-defined erythema and very slight to slight oedema were noted at all treated skin sites at the 24, 48 and 72-hour observations. The reaction extended approximately 3 cm beyond one treatment site at the 24, 48 and 72-hour observations. Blanching of the skin was noted at one treated skin site at the 24, 48 and 72-hour observations. Light brown discolouration of the epidermis was noted at the one treated skin site at the 72-hour observation. Loss of skin flexibility and/or elasticity was noted at two treated skin sites at the 48-hour observation and at all treated skin sites at the 72-hour observation. Crust formation was noted at all treated skin sites at the 7-day observation and prevented accurate evaluation of erythema and oedema at one treated skin site. Slight desquamation was noted at one treated skin site and two treated skin sites appeared normal at the 14-day observation. - Other effects:
- All animals showed expected gain in bodyweight during the study.
Applicant's summary and conclusion
- Interpretation of results:
- other: CLP/EU GHS criteria not met, no classification required according to Regulation (EC) No 1272/2008
- Conclusions:
- Vinyl benzoate was tested for skin irritation in 3 rabbits according to the OECD TG 404. With respect to the findings reported at reading time points 24, 48 and 72 h for the 3 animals, the resulting mean Draize scores for erythema and edema were < 2.3, respectively; thus no classification according the CLP Regulation is warranted and the compound is considered not to be a skin irritant according to the CLP criteria.
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