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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
Justification for type of information:
Data is from safety assessment report

Data source

Reference
Reference Type:
secondary source
Title:
SIDS dossier of p-Methoxybenzaldehyde
Author:
OECD SIDS
Year:
2009
Bibliographic source:
OECD HPV Chemical Programme, SIDS Dossier approved at SIAM 29 (20 - 23 October 2009)

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: Fed. Reg. 38, No. 187, § 1500.42
Principles of method if other than guideline:
An eye irritation study of p-Methoxybenzaldehyde (CAS No: 123-11-5) was conducted on Vienna White rabbits to determine the degree of eye irritancy caused by the chemical.
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
other: Liquid
Details on test material:
- Name of test material (as cited in study report): p-methoxybenzaldehyde
- Molecular formula : C8H8O2
- Molecular weight : 136.149 g/mol
- Substance type: Organic
- Physical state: liquid
Specific details on test material used for the study:
- Name of test material (as cited in study report): Anisic aldehyde/ p-Anisaldehyde
- Molecular formula: C8H8O2
- Molecular weight: 136.1492 g/mol
- Substance type: organic
- Physical state: liquid
-Smiles: COc1ccc(C=O)cc1
-InChI: 1S/C8H8O2/c1-10-8-4-2-7(6-9)3-5-8/h2-6H,1H3

Test animals / tissue source

Species:
rabbit
Strain:
Vienna White
Details on test animals or tissues and environmental conditions:
- Source: Gaukler
- Weight at study initiation: male: 3.16 kg; mean of 2 females: 2.46 kg
- Diet (e.g. ad libitum): Ssniff, Intermast

Test system

Vehicle:
unchanged (no vehicle)
Controls:
yes
Amount / concentration applied:
100% (0.1mL)
Duration of treatment / exposure:
Single application
Observation period (in vivo):
72 hours
Number of animals or in vitro replicates:
3
Details on study design:
REMOVAL OF TEST SUBSTANCE
- Washing (if done): The substance was not washed out

SCORING SYSTEM: according to Draize
TOOL USED TO ASSESS SCORE: fluorescein (only at the final reading)

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
cornea opacity score
Basis:
mean
Time point:
24/48/72 h
Score:
0
Max. score:
4
Reversibility:
not specified
Remarks on result:
no indication of irritation
Irritation parameter:
iris score
Basis:
mean
Time point:
24/48/72 h
Score:
0
Max. score:
2
Reversibility:
not specified
Remarks on result:
no indication of irritation
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
24/48/72 h
Score:
0.44
Max. score:
3
Reversibility:
fully reversible within: 72 hours
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
Moderate discharge was observed 1 h and slight discharge was observed 24 h after application in 3/3 animals. All the observed effects were reversible within 72 hours.

Any other information on results incl. tables

OBSERVATION TABLE

Ocular reactions

Animal no

1 hour

24 hours

48 hours

72 hours

Opacity

1

0

0

0

0

2

0

0

0

0

3

0

0

0

0

Mean:0.00

Cornea area

1

0

0

0

0

2

0

0

0

0

3

0

0

0

0

Mean:0.00

Iritis

1

0

0

0

0

2

0

0

0

0

3

0

0

0

0

Mean:0.00

Redness

1

2

1

0

0

2

2

1

1

0

3

1

1

0

0

Mean:0.44

Chemosis

1

1

0

0

0

2

1

0

0

0

3

2

0

0

0

Mean:0.00

Discharge

1

2

1

0

0

2

2

1

0

0

3

2

1

0

0

Applicant's summary and conclusion

Interpretation of results:
other: Not irritating
Conclusions:
The test material p-Methoxybenzaldehyde (CAS No: 123-11-5) was considered to be not irritating to the eyes of Vienna White rabbits.
Executive summary:

Skin irritation study of p-Methoxybenzaldehyde (CAS No: 123-11-5) was conducted on three Vienna White rabbits to determine the degree of eye irritancy.

 

The undiluted chemical was instilled into the eye of each rabbit and eyes were not rinsed. The eyes were scored according toDraize method.

 

Moderate discharge was observed 1 h and slight discharge was observed 24 h after application in 3/3 animals. All the observed effects were reversible within 72 hours.

 

According to the conditions of the test, the test substance does not fullfil the criteria of 67/548/EEC and GHS UN for classification, respectively. Therefore, the chemical p-Methoxybenzaldehyde (CAS No: 123-11-5) wasconsidered to be not irritating to theeyes of Vienna White rabbits.