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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from peer reviewed journal

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Fragrance material review on p-anisyl acetate
Author:
D. McGinty, C.S. Letizia, A.M. Api
Year:
2012
Bibliographic source:
Food and Chemical Toxicology, 50, (2012), S502–S506
Reference Type:
publication
Title:
Fundamental Studies of Safe Compound Perfumes for Cosmetics Part 1 The Primary Irritation of Compound Materials to the Skin
Author:
Toshio Takenaka, Eiko Hasegawa, Umeko Takenaka, Fumio Saito M. D. and Tazuko Odaka M. D
Year:
1968
Bibliographic source:
Journal of J.C.C.A. Special Issue (1968) Pg 313–329

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
A patch test of test chemical p-anisyl acetate (CAS No: 104-21-2) was conducted on 80 patients to assess its skin irritation potential.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
p-methoxybenzyl acetate
EC Number:
203-185-8
EC Name:
p-methoxybenzyl acetate
Cas Number:
104-21-2
Molecular formula:
C10H12O3
IUPAC Name:
4-methoxybenzyl acetate
Test material form:
not specified
Details on test material:
- Name of test material (as cited in study report): Anisyl acetate
- Molecular formula (if other than submission substance): C10-H12-O3
- Molecular weight (if other than submission substance): 180.202
- Substance type: Organic
- Physical state: No data available
- Purity 97%
- Impurities (identity and concentrations): No data available
Specific details on test material used for the study:
- Name of test material (as cited in study report): p- Anisyl acetate
- Molecular formula : C10-H12-O3
- Molecular weight: 180.202
- Substance type: Organic
- Physical state: liquid
- Smiles: c1(ccc(OC)cc1)COC(C)=O
- InChI: 1S/C10H12O3/c1-8(11)13-7-9-3-5-10(12-2)6-4-9/h3-6H,7H2,1-2H3

Test animals

Species:
human
Strain:
other: not applicable
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: Tokyo, Osaka
- Age at study initiation:16-45 yrs of age
- Weight at study initiation: No data available
- Fasting period before study: No data available
- Housing: No data available
- Diet (e.g. ad libitum): No data available
- Water (e.g. ad libitum): No data available
- Acclimation period: No data available


ENVIRONMENTAL CONDITIONS
- Temperature (°C): No data available
- Humidity (%): No data available
- Air changes (per hr): No data available
- Photoperiod (hrs dark / hrs light): No data available

IN-LIFE DATES: From: To: September 1963- December 1967

Test system

Type of coverage:
occlusive
Preparation of test site:
not specified
Vehicle:
other: Cream base or 99% ethyl alcohol
Controls:
yes, concurrent vehicle
Amount / concentration applied:
0.05-0.5 %
Duration of treatment / exposure:
24-48 hrs
Observation period:
30 mins after patch removal
Number of animals:
80 humans
Details on study design:
TEST SITE
- Area of exposure: back, forearm (flexor) and upperarm (inside flexion side)
- % coverage: No data available
- Type of wrap if used: No data available

REMOVAL OF TEST SUBSTANCE
- Washing (if done): No data available
- Time after start of exposure: No data available

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: 30 min after patch removal
Score:
0
Reversibility:
no data
Remarks on result:
other: No irritation was observed
Irritant / corrosive response data:
No irritation was noted in any of the treated human.

Applicant's summary and conclusion

Interpretation of results:
other: not irritating
Conclusions:
The test material anisyl acetate (CAS No: 104-21-2) when applied as a patch did not show any reaction. This suggests Anisyl acetate to be non irritant to the skin.
Executive summary:

A patch test of test chemical p-anisyl acetate (CAS No: 104-21-2) was conducted on 80 patients to assess its skin irritation potential

 

Anisyl acetate was applied as a closed patch to the back, forearm and upperarm of 80 male/female humans in Japan. The test material was applied at a concentration of 0.05-0.5%. Cream base or ethyl alcohol was used as a vehicle.

 

The patches were applied for 24–48 h and the sites evaluated 30 min after the patches were removed.

 

No irritation was noted in any of the human (0/80). ThereforeAnisyl acetate(CAS No: 104-21-2) was considered to be non-irritant to the skin.