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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Justification for type of information:
data is from safety assessment reports

Data source

Reference
Reference Type:
secondary source
Title:
IUCLID Dataset for the CAS: 90604-31-2
Author:
EUROPEAN COMMISSION – European Chemicals Bureau
Year:
2000
Bibliographic source:
IUCLID Dataset, EUROPEAN COMMISSION – European Chemicals Bureau, 2000

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Directive 84/449/EEC, B.4 "Acute toxicity (skin irritation)"
Principles of method if other than guideline:
The dermal irritation potential of Alcohols, C13-C15 was evaluated in rabbits following the method prescribed in Directive 84/449/EEC, B.4 "Acute toxicity (skin irritation)"
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Alcohols, C13-15
EC Number:
292-324-6
EC Name:
Alcohols, C13-15
Cas Number:
90604-31-2
Molecular formula:
C15H32O
IUPAC Name:
Alcohols, C13-15
Test material form:
liquid
Details on test material:
- Name of test material: Alcohols, C13-15
- IUPAC name: Alcohols, C13-15
- Molecular formula:C15H32O
- Molecular weight: 228 g/mole
- Substance type: Organic
- Physical state: Liquid
Specific details on test material used for the study:
- Name of test material: Alcohols, C13-15
- IUPAC name: Alcohols, C13-15
- Molecular formula: C13H280 + C15H32O
- Molecular weight: 208.78 g/mole
- Substance type: Organic
- Physical state: Liquid

Test animals

Species:
rabbit
Strain:
not specified
Details on test animals or test system and environmental conditions:
No data available

Test system

Type of coverage:
not specified
Preparation of test site:
not specified
Vehicle:
not specified
Controls:
not specified
Amount / concentration applied:
No data available
Duration of treatment / exposure:
No data available
Observation period:
No data available
Number of animals:
No data available
Details on study design:
No data available

Results and discussion

In vitro

Other effects / acceptance of results:
No data available

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: No data available
Reversibility:
not specified
Remarks on result:
probability of moderate irritation
Irritant / corrosive response data:
Moderate irritation observed

Applicant's summary and conclusion

Interpretation of results:
Category 2 (irritant) based on GHS criteria
Conclusions:
Alcohols, C13-C15 causes moderate irritation to rabbit skin.
Hence, Alcohols, C13-C15 can be considered to be irritating to skin.
Executive summary:

The dermal irritation potential of Alcohols, C13-C15 was evaluated in rabbits following the method prescribed in Directive 84/449/EEC, B.4 "Acute toxicity (skin irritation)".

Alcohols, C13-C15 was applied to the skin of rabbits and observed for signs of irritation (dose, duration and observation period not mentioned).

Alcohols, C13-C15 causes moderate irritation to rabbit skin.

Hence, Alcohols, C13-C15 can be considered to be irritating to skin.