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Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
23 June 2015 to 10 September 2015
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to same study
Reason / purpose for cross-reference:
reference to same study
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Version / remarks:
European Community (EC), EC no. 761/2009, Part A: Methods for the Determination of Physico-Chemical Properties, Guideline A.4: “Vapour Pressure", Official Journal of the European Union no. L220, August 24, 2009.
Deviations:
no
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Version / remarks:
Organization for Economic Co-operation and Development (OECD), OECD Guidelines for the Testing of Chemicals no.104: "Vapour Pressure", March 23, 2006.
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7950 (Vapor Pressure)
Version / remarks:
United States Environmental Protection Agency (EPA), Product Properties Test Guidelines no. OPPTS 830.7950: "Vapor pressure", August 1996.
Deviations:
no
GLP compliance:
yes
Type of method:
effusion method: isothermal thermogravimetry
Specific details on test material used for the study:
Identification: 2,2'-methylenebis[6-(1-methylcyclohexyl)-p-cresol]
Appearance: White to cream powder
Batch: WWP4J0001
Purity/Composition: 92.2%
Test substance storage: At room temperature
Stable under storage conditions until: 03 September 2018 (retest date)
Purity/composition correction factor: Yes, correction factor is according to purity
Test substance handling: No specific handling conditions required
Temp.:
20 °C
Vapour pressure:
0 Pa
Temp.:
20 °C
Vapour pressure:
0 mm Hg
Temp.:
25 °C
Vapour pressure:
0 Pa
Temp.:
25 °C
Vapour pressure:
0 mm Hg

The equation of the curve was: log PT= -6104 x 1/T + 14.58 (r = 0.9997, n = 8).

 

Results of the isothermal TGA analysis

Temperature

[°C]

Weight loss

[μg/min]

vT

[g/cm2/h]

Log vT

Log PT

PT

[Pa]

170

4.295

4.543

5.13 x 10-4

5.42 x 10-4

-3.29

-3.27

0.80

0.83

6.3

6.7

180

7.825

7.966

9.34 x 10-4

9.51 x 10-4

-3.03

-3.02

1.10

1.11

13

13

190

14.03

13.99

1.67 x 10-3

1.67 x 10-3

-2.78

-2.78

1.40

1.40

25

25

200

24.55

24.56

2.93 x 10-3

2.93 x 10-3

-2.53

-2.53

1.69

1.69

49

49

 

Vapour pressure of the test substance

Temperature

[°C]

Log PT

PT

[Pa]

PT

[mm Hg]

20

 

25

-6.24

 

-5.89

5.8 x 10-7

 

1.3 x 10-6

4.3 x 10-9

 

9.7 x 10-9

 

Conclusions:
≤ 5.8 e-7 Pa; ≤ 4.3 e-9 mm Hg at 20°C
≤ 1.3e-6 Pa; ≤ 9.7e-9 mm Hg at 25°C
Executive summary:

The aim of the study was to determine the physico-chemical properties for 2,2'-methylenebis[6-(1-methylcyclohexyl)-p-cresol].

 

The study was based on the following guidelines:

European Community (EC), EC no. 761/2009, Part A: Methods for the Determination of Physico-Chemical Properties, Guideline A.4: “Vapour Pressure", Official Journal of the European Union no. L220, August 24, 2009.

Organization for Economic Co-operation and Development (OECD), OECD Guidelines for the Testing of Chemicals no.104: "Vapour Pressure", March 23, 2006.

United States Environmental Protection Agency (EPA), Product Properties Test Guidelines no. OPPTS 830.7950: "Vapor pressure", August 1996.

 

The isothermal TGA effusion method was applied for the determination of the vapour pressure of 2,2'-methylenebis[6-(1-methylcyclohexyl)-p-cresol]. The weight losses of the test substance were obtained at temperatures above the melting temperature of the test substance because no significant weight loss of the test substance was observed below the melting temperature. According to this, the vapour pressure at 20°C and 25°C might be overestimated.

The vapour pressure of the test substance at 20°C (293K) and 25°C (298K) was therefore reported as equal or less than values:

 

 

20°C

25°C

[Pa]

[mm Hg]

[Pa]

[mm Hg]

Test substance

≤ 5.8 x 10-7

≤ 4.3 x 10-9

≤ 1.3 x 10-6

≤ 9.7 x 10-9

Description of key information

Key value determined in a GLP accredited laboratory study using the isothermal TGA effusion method, performed in accordance with EU MEthod A.4, OECD Guideline 104 and US EPA Procedure OPPTS 830.7950.

Key value for chemical safety assessment

Vapour pressure:
0 Pa
at the temperature of:
20 °C

Additional information

The isothermal TGA effusion method was applied for the determination of the vapour pressure of 2,2'-methylenebis[6-(1-methylcyclohexyl)-p-cresol]. The weight losses of the test substance were obtained at temperatures above the melting temperature of the test substance because no significant weight loss of the test substance was observed below the melting temperature. According to this, the vapour pressure at 20°C and 25°C might be overestimated.

The vapour pressure of the test substance at 20°C (293K) and 25°C (298K) was therefore reported as equal or less than values:

 

 

20°C

25°C

[Pa]

[mm Hg]

[Pa]

[mm Hg]

Test substance

≤ 5.8 x 10-7

≤ 4.3 x 10-9

≤ 1.3 x 10-6

≤ 9.7 x 10-9