2,3,3-trimethyl-3H-indole-5-carboxylic acid

Flammability

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

flammable solids

Type of information:

experimental study

Adequacy of study:

other information

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

UN Manual of Tests and Criteria: Test N.1 (Test method for readily combustible solids)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.10 (Flammability (Solids))

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Specific details on test material used for the study:

BTS sample no. 122875

Test procedure:

burning rate test: preliminary screening test

Burning time:

3 s

Remarks on result:

substance does not ignite and propagate combustion either by burning with flame or smouldering along 200 mm of the powder train within the 2 minutes test period

The test item melted when approached by the burner flame. The test item stopped burning after 3 seconds after removal of the flame. A burning off of the complete powder train was not observed.

The performance of the full test wasn’t necessary.

Interpretation of results:

not classified based on GHS criteria

Conclusions:

2,3,3-trimethyl-3H-indole-5-carboxylic acid is classified as a not readily combustible solid when tested according to UN N.1 (Recommendations on the Transport of Dangerous Goods - Manual of Tests and Criteria (UN-MTC)) and EC A.10 (Guideline EC 440/2008).

Executive summary:

A preliminary screening test was performed according to UN N.1 (Recommendations on the Transport of Dangerous Goods - Manual of Tests and Criteria (UN-MTC)) and EC A.10 (Guideline EC 440/2008) with 2,3,3-trimethyl-3H-indole-5-carboxylic acid to determine if propagation by burning with flame or smoldering occurs without wetted zone. The substance was formed into a powder train about 250 mm long by about 20 mm wide by about 10 mm high on a non-combustible, nonporous and low heat-conducting base plate.

2,3,3-trimethyl-3H-indole-5-carboxylic acid melted on approach of the burner flame. The test item burned for about 3 seconds after removal of the burner flame, than the test item stopped burning. A burning off of the complete powder train was not observed. The performance of the full test wasn't necessary.

Thus, 2,3,3-trimethyl-3H-indole-5-carboxylic acid is classified as a not readily combustible solid.

Reference 2

Endpoint:

self-heating substances / mixtures

Type of information:

experimental study

Adequacy of study:

other information

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

UN Manual of Tests and Criteria: Test N.4 (Test method for self-heating substances)

Qualifier:

according to guideline

Guideline:

other: EU Method A.16 (Relative self-ignition temperature for solids)

Version / remarks:

Screening test, similar to Grewer oven test

GLP compliance:

yes (incl. QA statement)

Specific details on test material used for the study:

BTS sample no. 122875

Test procedure:

other: Grewer oven test

Result:

negative outcome (no effect observed)

After the test, the basket of the sample was nearly empty (little black residue at the bottom).

Interpretation of results:

not classified based on GHS criteria

Conclusions:

2,3,3-trimethyl-3H-indole-5-carboxylic acid is not liable to self-heating.

Executive summary:

The self-heating temperature of 2,3,3-trimethyl-3H-indole-5-carboxylic acid has been conducted according to UN N.4 (Recommendations on the Transport of Dangerous Goods - Manual of Tests and Criteria (UN-MTC). The test according to EC A.16 (Relative Self-Ignition Temperature) was used as a screening test. This test method is very similar to the Grewer oven test (VOl guideline 2263, part 1, 1990).

2,3,3-trimethyl-3H-indole-5-carboxylic acid was placed in a wire basket with 8 mL volume in an oven at room temperature. The oven was heated up with a rate of 0.5 K/min up to 420 °C. The temperature of the center of the sample and the temperature of an inert reference sample, which was placed in the oven too, were recorded.

In the temperature diagram no exothermic reactions are visible. After the test, the basket of the sample was nearly empty (little black residue at the bottom).

2,,3,3-trimethyl-3H-indole-5-carboxylic acid is not liable to self-heating.

Reference 3

Endpoint:

substances / mixtures which in contact with water emit flammable gases

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

the study does not need to be conducted because the organic substance does not contain metals or metalloids and hence, the classification procedure does not need to be applied

Interpretation of results:

not classified based on GHS criteria

Conclusions:

The substance does not ignite spontaneously with water and does not liberate gases in hazardous amounts.

Executive summary:

The chemical structure of the substance contains no metals or metalloids. Testing according to UN-MTC procedure N.5 and EC A.12 is not necessary with reference to Appendix 6, chapter 5.3 of UN-MTC.

The substance does not ignite spontaneously with water and does not liberate gases in hazardous amounts.

Reference 4

Endpoint:

pyrophoric solids

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

other:

Interpretation of results:

not classified based on GHS criteria

Executive summary:

The test substance did not deliver indications of pyrophoric properties during the realization of other tests. Testing according to procedure N.2 and EC A.13 is not necessary.

The substance is classified with "no pyrophoric properties"

Description of key information

Flammability:

2,3,3-trimethyl-3H-indole-5-carboxylic acid is classified as a not readily combustible solid when tested according to UN N.1 and EC A.10.

Contact with water:

The chemical structure of the substance contains no metals or metalloids. Thus the substance does not ignite spontaneously with water and does not liberate gases in hazardous amounts.

Pyrophoric properties:

The test substance did not deliver indications of pyrophoric properties during the realization of other tests. So the substance is classified with "no pyrophoric properties".

Self-heating:

2,3,3-trimethyl-3H-indole-5-carboxylic acid is not liable to self-heating when tested according to UN N.4 (screening test according to EC A.16).

Key value for chemical safety assessment

Flammability:

not classified

Justification for classification or non-classification

According to available data 2,3,3-trimethyl-3H-indole-5-carboxylic acid is not classified as flammable, self-heating or pyrophoric. Furthermore it does not ignite spontaneously with water and does not liberate gases in hazardous amounts.